Search Results

Overview

Uniprot IDO15090
Protein NameZinc finger protein 536
Gene NameZNF536
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
181 KIHLRTHKLGNLGKG
383 QICGRRFKEPWFLKN
597 SQRDLPSKLDPLESS

Function

Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription (PubMed:19398580). Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580). Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' (PubMed:14621294)

Protein Sequence

10 MEEASLCLGV 20 SSAEPEAEPH 30 LSGPVLNGQY 40 AMSQKLHQIT 50 SQLSHAFPEL 60 HPRPNPEEKP 70 PASLEEKAHV 80 PMSGQPMGSQ 90 MALLANQLGR 100 EVDTSLNGRV 110 DLQQFLNGQN 120 LGIMSQMSDI 130 EDDARKNRKY 140 PCPLCGKRFR 150 FNSILSLHMR 160 THTGEKPFKC 170 PYCDHRAAQK 180 GNLKIHLRTH 190 KLGNLGKGRG 200 RVREENRLLH 210 ELEERAILRD 220 KQLKGSLLQP 230 RPDLKPPPHA 240 QQAPLAACTL 250 ALQANHSVPD 260 VAHPVPSPKP 270 ASVQEDAVAP 280 AAGFRCTFCK 290 GKFKKREELD 300 RHIRILHKPY 310 KCTLCDFAAS 320 QEEELISHVE 330 KAHITAESAQ 340 GQGPNGGGEQ 350 SANEFRCEVC 360 GQVFSQAWFL 370 KGHMRKHKDS 380 FEHCCQICGR 390 RFKEPWFLKN 400 HMKVHLNKLS 410 VKNKSPSDPE 420 VPVPMGGMSQ 430 EAHANLYSRY 440 LSCLQSGFMT 450 PDKAGLSEPS 460 QLYGKGELPM 470 KEKEALGKLL 480 SPISSMAHGV 490 PEGDKHSLLG 500 CLNLVPPLKS 510 SCIERLQAAA 520 KAAEMDPVNS 530 YQAWQLMARG 540 MAMEHGFLSK 550 EHPLQRNHED 560 TLANAGVLFD 570 KEKREYVLVG 580 ADGSKQKMPA 590 DLVHSTKVGS 600 QRDLPSKLDP 610 LESSRDFLSH 620 GLNQTLEYNL 630 QGPGNMKEKP 640 TECPDCGRVF 650 RTYHQVVVHS 660 RVHKRDRKGE 670 EDGLHVGLDE 680 RRGSGSDQES 690 QSVSRSTTPG 700 SSNVTEESGV 710 GGGLSQTGSA 720 QEDSPHPSSP 730 SSSDIGEEAG 740 RSAGVQQPAL 750 LRDRSLGSAM 760 KDCPYCGKTF 770 RTSHHLKVHL 780 RIHTGEKPYK 790 CPHCDYAGTQ 800 SASLKYHLER 810 HHRERQNGAG 820 PLSGQPPNQD 830 HKDEMSSKAS 840 LFIRPDILRG 850 AFKGLPGIDF 860 RGGPASQQWT 870 SGVLSSGDHS 880 GQATGMSSEV 890 PSDALKGTDL 900 PSKSTHFSEI 910 GRAYQSIVSN 920 GVNFQGSLQA 930 FMDSFVLSSL 940 KKEKDMKDKA 950 LADPPSMKVH 960 GVDGGEEKPS 970 GKSSQRKSEK 980 SQYEPLDLSV 990 RPDAASLPGS 1000 SVTVQDSIAW 1010 HGCLFCAFTT 1020 SSMELMALHL 1030 QANHLGKAKR 1040 KDNTIGVTVN 1050 CKDQAREASK 1060 MALLPSLQSN 1070 KDLGLSNMIS 1080 SLDSASEKMA 1090 QGQLKETLGE 1100 QKSGAWTGHV 1110 DPAFCNFPSD 1120 FYKQFGVYPG 1130 MVGSGASSSC 1140 PNKEPDGKAH 1150 SEEDVPILIP 1160 ETTSKNTTDD 1170 LSDIASSEDM 1180 DSSKGENNDE 1190 EDVETEPEMM 1200 TKPLSALSKD 1210 SSSDGGDSLQ 1220 PTGTSQPVQG 1230 LVSPLSQAPE 1240 KQWHSQGLLQ 1250 AQDPLAGLPK 1260 PERGPQSLDK 1270 PMNMLSVLRA 1280 YSSDGLAAFN 1290 GLASSTANSG 1300 CIKRPDLCGK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

PMID: N/A