Search Results

Overview

Uniprot ID	O15173
Protein Name	Membrane-associated progesterone receptor component 2
Gene Name	PGRMC2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
135	FDVTKGSKFYGPAGP
193	WEMQFKEKYDYVGRL

Function

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity)

Protein Sequence

10 MAAGDGDVKL 20 GTLGSGSESS 30 NDGGSESPGD 40 AGAAAEGGGW 50 AAAALALLTG 60 GGEMLLNVAL 70 VALVLLGAYR 80 LWVRWGRRGL 90 GAGAGAGEES 100 PATSLPRMKK 110 RDFSLEQLRQ 120 YDGSRNPRIL 130 LAVNGKVFDV 140 TKGSKFYGPA 150 GPYGIFAGRD 160 ASRGLATFCL 170 DKDALRDEYD 180 DLSDLNAVQM 190 ESVREWEMQF 200 KEKYDYVGRL 210 LKPGEEPSEY 220 TDEEDTKDHN KQD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0012505	endomembrane system
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0020037	heme binding
Molecular Function	GO:0015232	heme transmembrane transporter activity
Molecular Function	GO:0003707	nuclear steroid receptor activity
Molecular Function	GO:0005496	steroid binding
Biological Process	GO:0060612	adipose tissue development

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.