Search Results
Overview
| Uniprot ID | O15212 |
|---|---|
| Protein Name | Prefoldin subunit 6 |
| Gene Name | PFDN6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | FQRAQAAKAGAPGKA |
| 21 | EKYQQLQKDLSKSMS |
| 8 | MAELIQKKLQGEVEK |
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins
Protein Sequence
10
MAELIQKKLQ
20
GEVEKYQQLQ
30
KDLSKSMSGR
40
QKLEAQLTEN
50
NIVKEELALL
60
DGSNVVFKLL
70
GPVLVKQELG
80
EARATVGKRL
90
DYITAEIKRY
100
ESQLRDLERQ
110
SEQQRETLAQ
120
LQQEFQRAQA
AKAGAPGKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016272 | prefoldin complex |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0051131 | chaperone-mediated protein complex assembly |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.