Overview
| Uniprot ID | O15213 |
|---|
| Protein Name | WD repeat-containing protein 46 |
|---|
| Gene Name | WDR46 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 65 |
PKNAYILKKSRISKK |
| 66 |
KNAYILKKSRISKKP |
Function
Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)
Protein Sequence
10
METAPKPGKD
20
VPPKKDKLQT
30
KRKKPRRYWE
40
EETVPTTAGA
50
SPGPPRNKKN
60
RELRPQRPKN
70
AYILKKSRIS
80
KKPQVPKKPR
90
EWKNPESQRG
100
LSGTQDPFPG
110
PAPVPVEVVQ
120
KFCRIDKSRK
130
LPHSKAKTRS
140
RLEVAEAEEE
150
ETSIKAARSE
160
LLLAEEPGFL
170
EGEDGEDTAK
180
ICQADIVEAV
190
DIASAAKHFD
200
LNLRQFGPYR
210
LNYSRTGRHL
220
AFGGRRGHVA
230
ALDWVTKKLM
240
CEINVMEAVR
250
DIRFLHSEAL
260
LAVAQNRWLH
270
IYDNQGIELH
280
CIRRCDRVTR
290
LEFLPFHFLL
300
ATASETGFLT
310
YLDVSVGKIV
320
AALNARAGRL
330
DVMSQNPYNA
340
VIHLGHSNGT
350
VSLWSPAMKE
360
PLAKILCHRG
370
GVRAVAVDST
380
GTYMATSGLD
390
HQLKIFDLRG
400
TYQPLSTRTL
410
PHGAGHLAFS
420
QRGLLVAGMG
430
DVVNIWAGQG
440
KASPPSLEQP
450
YLTHRLSGPV
460
HGLQFCPFED
470
VLGVGHTGGI
480
TSMLVPGAGE
490
PNFDGLESNP
500
YRSRKQRQEW
510
EVKALLEKVP
520
AELICLDPRA
530
LAEVDVISLE
540
QGKKEQIERL
550
GYDPQAKAPF
560
QPKPKQKGRS
570
STASLVKRKR
580
KVMDEEHRDK
590
VRQSLQQQHH
600
KEAKAKPTGA
610
RPSALDRFVR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0030490 |
maturation of SSU-rRNA |
| Biological Process |
GO:0000462 |
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.