Search Results

Overview

Uniprot IDO15226
Protein NameNF-kappa-B-repressing factor
Gene NameNKRF
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
234 ADIPKNKKLLTDGYA
28 LVLSKPSKGQKRHLS
44 CDGQNPPKKQAGSKF
45 DGQNPPKKQAGSKFH
561 IGNQLLRKMGWTGGG
68 HFVASSSKDERQEDP

Function

Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553)

Protein Sequence

10 MEKILQMAEG 20 IDIGEMPSYD 30 LVLSKPSKGQ 40 KRHLSTCDGQ 50 NPPKKQAGSK 60 FHARPRFEPV 70 HFVASSSKDE 80 RQEDPYGPQT 90 KEVNEQTHFA 100 SMPRDIYQDY 110 TQDSFSIQDG 120 NSQYCDSSGF 130 ILTKDQPVTA 140 NMYFDSGNPA 150 PSTTSQQANS 160 QSTPEPSPSQ 170 TFPESVVAEK 180 QYFIEKLTAT 190 IWKNLSNPEM 200 TSGSDKINYT 210 YMLTRCIQAC 220 KTNPEYIYAP 230 LKEIPPADIP 240 KNKKLLTDGY 250 ACEVRCQNIY 260 LTTGYAGSKN 270 GSRDRATELA 280 VKLLQKRIEV 290 RVVRRKFKHT 300 FGEDLVVCQI 310 GMSSYEFPPA 320 LKPPEDLVVL 330 GKDASGQPIF 340 NASAKHWTNF 350 VITENANDAI 360 GILNNSASFN 370 KMSIEYKYEM 380 MPNRTWRCRV 390 FLQDHCLAEG 400 YGTKKTSKHA 410 AADEALKILQ 420 KTQPTYPSVK 430 SSQCHTGSSP 440 RGSGKKKDIK 450 DLVVYENSSN 460 PVCTLNDTAQ 470 FNRMTVEYVY 480 ERMTGLRWKC 490 KVILESEVIA 500 EAVGVKKTVK 510 YEAAGEAVKT 520 LKKTQPTVIN 530 NLKKGAVEDV 540 ISRNEIQGRS 550 AEEAYKQQIK 560 EDNIGNQLLR 570 KMGWTGGGLG 580 KSGEGIREPI 590 SVKEQHKREG 600 LGLDVERVNK 610 IAKRDIEQII 620 RNYARSESHT 630 DLTFSRELTN 640 DERKQIHQIA 650 QKYGLKSKSH 660 GVGHDRYLVV 670 GRKRRKEDLL 680 DQLKQEGQVG 690 HYELVMPQAN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001671 ATPase activator activity
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.