Search Results

Overview

Uniprot ID	O15228
Protein Name	Dihydroxyacetone phosphate acyltransferase
Gene Name	GNPAT
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
312	ESTTGLLKARKILSE
645	LGVVEKKKINNNCIF

Function

Dihydroxyacetonephosphate acyltransferase catalyzing the first step in the biosynthesis of plasmalogens, a subset of phospholipids that differ from other glycerolipids by having an alkyl chain attached through a vinyl ether linkage at the sn-1 position of the glycerol backbone, and which unique physical properties have an impact on various aspects of cell signaling and membrane biology

Protein Sequence

10 MESSSSSNSY 20 FSVGPTSPSA 30 VVLLYSKELK 40 KWDEFEDILE 50 ERRHVSDLKF 60 AMKCYTPLVY 70 KGITPCKPID 80 IKCSVLNSEE 90 IHYVIKQLSK 100 ESLQSVDVLR 110 EEVSEILDEM 120 SHKLRLGAIR 130 FCAFTLSKVF 140 KQIFSKVCVN 150 EEGIQKLQRA 160 IQEHPVVLLP 170 SHRSYIDFLM 180 LSFLLYNYDL 190 PVPVIAAGMD 200 FLGMKMVGEL 210 LRMSGAFFMR 220 RTFGGNKLYW 230 AVFSEYVKTM 240 LRNGYAPVEF 250 FLEGTRSRSA 260 KTLTPKFGLL 270 NIVMEPFFKR 280 EVFDTYLVPI 290 SISYDKILEE 300 TLYVYELLGV 310 PKPKESTTGL 320 LKARKILSEN 330 FGSIHVYFGD 340 PVSLRSLAAG 350 RMSRSSYNLV 360 PRYIPQKQSE 370 DMHAFVTEVA 380 YKMELLQIEN 390 MVLSPWTLIV 400 AVLLQNRPSM 410 DFDALVEKTL 420 WLKGLTQAFG 430 GFLIWPDNKP 440 AEEVVPASIL 450 LHSNIASLVK 460 DQVILKVDSG 470 DSEVVDGLML 480 QHITLLMCSA 490 YRNQLLNIFV 500 RPSLVAVALQ 510 MTPGFRKEDV 520 YSCFRFLRDV 530 FADEFIFLPG 540 NTLKDFEEGC 550 YLLCKSEAIQ 560 VTTKDILVTE 570 KGNTVLEFLV 580 GLFKPFVESY 590 QIICKYLLSE 600 EEDHFSEEQY 610 LAAVRKFTSQ 620 LLDQGTSQCY 630 DVLSSDVQKN 640 ALAACVRLGV 650 VEKKKINNNC 660 IFNVNEPATT 670 KLEEMLGCKT 680 PIGKPATAKL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005782	peroxisomal matrix
Cellular Component	GO:0005778	peroxisomal membrane
Cellular Component	GO:0005777	peroxisome
Molecular Function	GO:0016287	glycerone-phosphate O-acyltransferase activity
Biological Process	GO:0008611	ether lipid biosynthetic process
Biological Process	GO:0006654	phosphatidic acid biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.