Search Results

Overview

Uniprot IDO15230
Protein NameLaminin subunit alpha-5
Gene NameLAMA5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2481 TFSPAGSKLRLVEAA

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2 (PubMed:33242826)

Protein Sequence

10 MAKRLCAGSA 20 LCVRGPRGPA 30 PLLLVGLALL 40 GAARAREEAG 50 GGFSLHPPYF 60 NLAEGARIAA 70 SATCGEEAPA 80 RGSPRPTEDL 90 YCKLVGGPVA 100 GGDPNQTIRG 110 QYCDICTAAN 120 SNKAHPASNA 130 IDGTERWWQS 140 PPLSRGLEYN 150 EVNVTLDLGQ 160 VFHVAYVLIK 170 FANSPRPDLW 180 VLERSMDFGR 190 TYQPWQFFAS 200 SKRDCLERFG 210 PQTLERITRD 220 DAAICTTEYS 230 RIVPLENGEI 240 VVSLVNGRPG 250 AMNFSYSPLL 260 REFTKATNVR 270 LRFLRTNTLL 280 GHLMGKALRD 290 PTVTRRYYYS 300 IKDISIGGRC 310 VCHGHADACD 320 AKDPTDPFRL 330 QCTCQHNTCG 340 GTCDRCCPGF 350 NQQPWKPATA 360 NSANECQSCN 370 CYGHATDCYY 380 DPEVDRRRAS 390 QSLDGTYQGG 400 GVCIDCQHHT 410 TGVNCERCLP 420 GFYRSPNHPL 430 DSPHVCRRCN 440 CESDFTDGTC 450 EDLTGRCYCR 460 PNFSGERCDV 470 CAEGFTGFPS 480 CYPTPSSSND 490 TREQVLPAGQ 500 IVNCDCSAAG 510 TQGNACRKDP 520 RVGRCLCKPN 530 FQGTHCELCA 540 PGFYGPGCQP 550 CQCSSPGVAD 560 DRCDPDTGQC 570 RCRVGFEGAT 580 CDRCAPGYFH 590 FPLCQLCGCS 600 PAGTLPEGCD 610 EAGRCLCQPE 620 FAGPHCDRCR 630 PGYHGFPNCQ 640 ACTCDPRGAL 650 DQLCGAGGLC 660 RCRPGYTGTA 670 CQECSPGFHG 680 FPSCVPCHCS 690 AEGSLHAACD 700 PRSGQCSCRP 710 RVTGLRCDTC 720 VPGAYNFPYC 730 EAGSCHPAGL 740 APVDPALPEA 750 QVPCMCRAHV 760 EGPSCDRCKP 770 GFWGLSPSNP 780 EGCTRCSCDL 790 RGTLGGVAEC 800 QPGTGQCFCK 810 PHVCGQACAS 820 CKDGFFGLDQ 830 ADYFGCRSCR 840 CDIGGALGQS 850 CEPRTGVCRC 860 RPNTQGPTCS 870 EPARDHYLPD 880 LHHLRLELEE 890 AATPEGHAVR 900 FGFNPLEFEN 910 FSWRGYAQMA 920 PVQPRIVARL 930 NLTSPDLFWL 940 VFRYVNRGAM 950 SVSGRVSVRE 960 EGRSATCANC 970 TAQSQPVAFP 980 PSTEPAFITV 990 PQRGFGEPFV 1000 LNPGTWALRV 1010 EAEGVLLDYV 1020 VLLPSAYYEA 1030 ALLQLRVTEA 1040 CTYRPSAQQS 1050 GDNCLLYTHL 1060 PLDGFPSAAG 1070 LEALCRQDNS 1080 LPRPCPTEQL 1090 SPSHPPLITC 1100 TGSDVDVQLQ 1110 VAVPQPGRYA 1120 LVVEYANEDA 1130 RQEVGVAVHT 1140 PQRAPQQGLL 1150 SLHPCLYSTL 1160 CRGTARDTQD 1170 HLAVFHLDSE 1180 ASVRLTAEQA 1190 RFFLHGVTLV 1200 PIEEFSPEFV 1210 EPRVSCISSH 1220 GAFGPNSAAC 1230 LPSRFPKPPQ 1240 PIILRDCQVI 1250 PLPPGLPLTH 1260 AQDLTPAMSP 1270 AGPRPRPPTA 1280 VDPDAEPTLL 1290 REPQATVVFT 1300 THVPTLGRYA 1310 FLLHGYQPAH 1320 PTFPVEVLIN 1330 AGRVWQGHAN 1340 ASFCPHGYGC 1350 RTLVVCEGQA 1360 LLDVTHSELT 1370 VTVRVPKGRW 1380 LWLDYVLVVP 1390 ENVYSFGYLR 1400 EEPLDKSYDF 1410 ISHCAAQGYH 1420 ISPSSSSLFC 1430 RNAAASLSLF 1440 YNNGARPCGC 1450 HEVGATGPTC 1460 EPFGGQCPCH 1470 AHVIGRDCSR 1480 CATGYWGFPN 1490 CRPCDCGARL 1500 CDELTGQCIC 1510 PPRTIPPDCL 1520 LCQPQTFGCH 1530 PLVGCEECNC 1540 SGPGIQELTD 1550 PTCDTDSGQC 1560 KCRPNVTGRR 1570 CDTCSPGFHG 1580 YPRCRPCDCH 1590 EAGTAPGVCD 1600 PLTGQCYCKE 1610 NVQGPKCDQC 1620 SLGTFSLDAA 1630 NPKGCTRCFC 1640 FGATERCRSS 1650 SYTRQEFVDM 1660 EGWVLLSTDR 1670 QVVPHERQPG 1680 TEMLRADLRH 1690 VPEAVPEAFP 1700 ELYWQAPPSY 1710 LGDRVSSYGG 1720 TLRYELHSET 1730 QRGDVFVPME 1740 SRPDVVLQGN 1750 QMSITFLEPA 1760 YPTPGHVHRG 1770 QLQLVEGNFR 1780 HTETRNTVSR 1790 EELMMVLASL 1800 EQLQIRALFS 1810 QISSAVFLRR 1820 VALEVASPAG 1830 QGALASNVEL 1840 CLCPASYRGD 1850 SCQECAPGFY 1860 RDVKGLFLGR 1870 CVPCQCHGHS 1880 DRCLPGSGVC 1890 VDCQHNTEGA 1900 HCERCQAGFV 1910 SSRDDPSAPC 1920 VSCPCPLSVP 1930 SNNFAEGCVL 1940 RGGRTQCLCK 1950 PGYAGASCER 1960 CAPGFFGNPL 1970 VLGSSCQPCD 1980 CSGNGDPNLL 1990 FSDCDPLTGA 2000 CRGCLRHTTG 2010 PRCEICAPGF 2020 YGNALLPGNC 2030 TRCDCTPCGT 2040 EACDPHSGHC 2050 LCKAGVTGRR 2060 CDRCQEGHFG 2070 FDGCGGCRPC 2080 ACGPAAEGSE 2090 CHPQSGQCHC 2100 RPGTMGPQCR 2110 ECAPGYWGLP 2120 EQGCRRCQCP 2130 GGRCDPHTGR 2140 CNCPPGLSGE 2150 RCDTCSQQHQ 2160 VPVPGGPVGH 2170 SIHCEVCDHC 2180 VVLLLDDLER 2190 AGALLPAIHE 2200 QLRGINASSM 2210 AWARLHRLNA 2220 SIADLQSQLR 2230 SPLGPRHETA 2240 QQLEVLEQQS 2250 TSLGQDARRL 2260 GGQAVGTRDQ 2270 ASQLLAGTEA 2280 TLGHAKTLLA 2290 AIRAVDRTLS 2300 ELMSQTGHLG 2310 LANASAPSGE 2320 QLLRTLAEVE 2330 RLLWEMRARD 2340 LGAPQAAAEA 2350 ELAAAQRLLA 2360 RVQEQLSSLW 2370 EENQALATQT 2380 RDRLAQHEAG 2390 LMDLREALNR 2400 AVDATREAQE 2410 LNSRNQERLE 2420 EALQRKQELS 2430 RDNATLQATL 2440 HAARDTLASV 2450 FRLLHSLDQA 2460 KEELERLAAS 2470 LDGARTPLLQ 2480 RMQTFSPAGS 2490 KLRLVEAAEA 2500 HAQQLGQLAL 2510 NLSSIILDVN 2520 QDRLTQRAIE 2530 ASNAYSRILQ 2540 AVQAAEDAAG 2550 QALQQADHTW 2560 ATVVRQGLVD 2570 RAQQLLANST 2580 ALEEAMLQEQ 2590 QRLGLVWAAL 2600 QGARTQLRDV 2610 RAKKDQLEAH 2620 IQAAQAMLAM 2630 DTDETSKKIA 2640 HAKAVAAEAQ 2650 DTATRVQSQL 2660 QAMQENVERW 2670 QGQYEGLRGQ 2680 DLGQAVLDAG 2690 HSVSTLEKTL 2700 PQLLAKLSIL 2710 ENRGVHNASL 2720 ALSASIGRVR 2730 ELIAQARGAA 2740 SKVKVPMKFN 2750 GRSGVQLRTP 2760 RDLADLAAYT 2770 ALKFYLQGPE 2780 PEPGQGTEDR 2790 FVMYMGSRQA 2800 TGDYMGVSLR 2810 DKKVHWVYQL 2820 GEAGPAVLSI 2830 DEDIGEQFAA 2840 VSLDRTLQFG 2850 HMSVTVERQM 2860 IQETKGDTVA 2870 PGAEGLLNLR 2880 PDDFVFYVGG 2890 YPSTFTPPPL 2900 LRFPGYRGCI 2910 EMDTLNEEVV 2920 SLYNFERTFQ 2930 LDTAVDRPCA 2940 RSKSTGDPWL 2950 TDGSYLDGTG 2960 FARISFDSQI 2970 STTKRFEQEL 2980 RLVSYSGVLF 2990 FLKQQSQFLC 3000 LAVQEGSLVL 3010 LYDFGAGLKK 3020 AVPLQPPPPL 3030 TSASKAIQVF 3040 LLGGSRKRVL 3050 VRVERATVYS 3060 VEQDNDLELA 3070 DAYYLGGVPP 3080 DQLPPSLRRL 3090 FPTGGSVRGC 3100 VKGIKALGKY 3110 VDLKRLNTTG 3120 VSAGCTADLL 3130 VGRAMTFHGH 3140 GFLRLALSNV 3150 APLTGNVYSG 3160 FGFHSAQDSA 3170 LLYYRASPDG 3180 LCQVSLQQGR 3190 VSLQLLRTEV 3200 KTQAGFADGA 3210 PHYVAFYSNA 3220 TGVWLYVDDQ 3230 LQQMKPHRGP 3240 PPELQPQPEG 3250 PPRLLLGGLP 3260 ESGTIYNFSG 3270 CISNVFVQRL 3280 LGPQRVFDLQ 3290 QNLGSVNVST 3300 GCAPALQAQT 3310 PGLGPRGLQA 3320 TARKASRRSR 3330 QPARHPACML 3340 PPHLRTTRDS 3350 YQFGGSLSSH 3360 LEFVGILARH 3370 RNWPSLSMHV 3380 LPRSSRGLLL 3390 FTARLRPGSP 3400 SLALFLSNGH 3410 FVAQMEGLGT 3420 RLRAQSRQRS 3430 RPGRWHKVSV 3440 RWEKNRILLV 3450 TDGARAWSQE 3460 GPHRQHQGAE 3470 HPQPHTLFVG 3480 GLPASSHSSK 3490 LPVTVGFSGC 3500 VKRLRLHGRP 3510 LGAPTRMAGV 3520 TPCILGPLEA 3530 GLFFPGSGGV 3540 ITLDLPGATL 3550 PDVGLELEVR 3560 PLAVTGLIFH 3570 LGQARTPPYL 3580 QLQVTEKQVL 3590 LRADDGAGEF 3600 STSVTRPSVL 3610 CDGQWHRLAV 3620 MKSGNVLRLE 3630 VDAQSNHTVG 3640 PLLAAAAGAP 3650 APLYLGGLPE 3660 PMAVQPWPPA 3670 YCGCMRRLAV 3680 NRSPVAMTRS 3690 VEVHGAVGAS GCPAA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0098965 extracellular matrix of synaptic cleft
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005610 laminin-332 trimer
Cellular Component GO:0043259 laminin-511 trimer
Cellular Component GO:0043260 laminin-521 trimer
Cellular Component GO:1990339 laminin-522 trimer
Cellular Component GO:1990340 laminin-523 trimer
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0005634 nucleus
Cellular Component GO:0043083 synaptic cleft
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0048018 receptor ligand activity
Biological Process GO:0007155 cell adhesion
Biological Process GO:0016477 cell migration
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0099173 postsynapse organization
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0048705 skeletal system morphogenesis
Biological Process GO:0034446 substrate adhesion-dependent cell spreading

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.