Search Results
Overview
| Uniprot ID | O15247 |
|---|---|
| Protein Name | Chloride intracellular channel protein 2 |
| Gene Name | CLIC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 189 | ADCSLLPKLNIIKVA |
| 233 | THTCPEDKEIENTYA |
Function
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (Probable) (PubMed:25581026). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx
Protein Sequence
10
MSGLRPGTQV
20
DPEIELFVKA
30
GSDGESIGNC
40
PFCQRLFMIL
50
WLKGVKFNVT
60
TVDMTRKPEE
70
LKDLAPGTNP
80
PFLVYNKELK
90
TDFIKIEEFL
100
EQTLAPPRYP
110
HLSPKYKESF
120
DVGCNLFAKF
130
SAYIKNTQKE
140
ANKNFEKSLL
150
KEFKRLDDYL
160
NTPLLDEIDP
170
DSAEEPPVSR
180
RLFLDGDQLT
190
LADCSLLPKL
200
NIIKVAAKKY
210
RDFDIPAEFS
220
GVWRYLHNAY
230
AREEFTHTCP
240
EDKEIENTYA
NVAKQKS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034707 | chloride channel complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005254 | chloride channel activity |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Biological Process | GO:0006821 | chloride transport |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:0007165 | signal transduction |
Reference
PMID: N/A