Overview
| Uniprot ID | O15260 |
|---|
| Protein Name | Surfeit locus protein 4 |
|---|
| Gene Name | SURF4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 22 |
DQFLRVTKQYLPHVA |
Function
Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:29643117, PubMed:30251625, PubMed:33186557). Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:29643117, PubMed:33186557). Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed:33186557). Promotes the secretion of PCSK9 (PubMed:30251625). Also mediates the efficient secretion of erythropoietin (EPO) (PubMed:32989016). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed:18287528)
Protein Sequence
10
MGQNDLMGTA
20
EDFADQFLRV
30
TKQYLPHVAR
40
LCLISTFLED
50
GIRMWFQWSE
60
QRDYIDTTWN
70
CGYLLASSFV
80
FLNLLGQLTG
90
CVLVLSRNFV
100
QYACFGLFGI
110
IALQTIAYSI
120
LWDLKFLMRN
130
LALGGGLLLL
140
LAESRSEGKS
150
MFAGVPTMRE
160
SSPKQYMQLG
170
GRVLLVLMFM
180
TLLHFDASFF
190
SIVQNIVGTA
200
LMILVAIGFK
210
TKLAALTLVV
220
WLFAINVYFN
230
AFWTIPVYKP
240
MHDFLKYDFF
250
QTMSVIGGLL
260
LVVALGPGGV
SMDEKKKEW
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0035577 |
azurophil granule membrane |
| Cellular Component |
GO:0005793 |
endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component |
GO:0033116 |
endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0030133 |
transport vesicle |
| Molecular Function |
GO:0038024 |
cargo receptor activity |
| Molecular Function |
GO:0097020 |
COPII receptor activity |
| Biological Process |
GO:0090110 |
COPII-coated vesicle cargo loading |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0007030 |
Golgi organization |
| Biological Process |
GO:0140353 |
lipid export from cell |
| Biological Process |
GO:0055088 |
lipid homeostasis |
| Biological Process |
GO:0042953 |
lipoprotein transport |
| Biological Process |
GO:0010638 |
positive regulation of organelle organization |
| Biological Process |
GO:0032368 |
regulation of lipid transport |
| Cellular Component |
GO:0030134 |
COPII-coated ER to Golgi transport vesicle |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0070971 |
endoplasmic reticulum exit site |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.