Overview
| Uniprot ID | O15264 |
|---|
| Protein Name | Mitogen-activated protein kinase 13 |
|---|
| Gene Name | MAPK13 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 45 |
SVCSAIDKRSGEKVA |
Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells
Protein Sequence
10
MSLIRKKGFY
20
KQDVNKTAWE
30
LPKTYVSPTH
40
VGSGAYGSVC
50
SAIDKRSGEK
60
VAIKKLSRPF
70
QSEIFAKRAY
80
RELLLLKHMQ
90
HENVIGLLDV
100
FTPASSLRNF
110
YDFYLVMPFM
120
QTDLQKIMGM
130
EFSEEKIQYL
140
VYQMLKGLKY
150
IHSAGVVHRD
160
LKPGNLAVNE
170
DCELKILDFG
180
LARHADAEMT
190
GYVVTRWYRA
200
PEVILSWMHY
210
NQTVDIWSVG
220
CIMAEMLTGK
230
TLFKGKDYLD
240
QLTQILKVTG
250
VPGTEFVQKL
260
NDKAAKSYIQ
270
SLPQTPRKDF
280
TQLFPRASPQ
290
AADLLEKMLE
300
LDVDKRLTAA
310
QALTHPFFEP
320
FRDPEEETEA
330
QQPFDDSLEH
340
EKLTVDEWKQ
350
HIYKEIVNFS
360
PIARKDSRRR
SGMKL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004707 |
MAP kinase activity |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Biological Process |
GO:0072740 |
cellular response to anisomycin |
| Biological Process |
GO:0070301 |
cellular response to hydrogen peroxide |
| Biological Process |
GO:0071347 |
cellular response to interleukin-1 |
| Biological Process |
GO:1903936 |
cellular response to sodium arsenite |
| Biological Process |
GO:0072709 |
cellular response to sorbitol |
| Biological Process |
GO:0034644 |
cellular response to UV |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0050729 |
positive regulation of inflammatory response |
| Biological Process |
GO:0032755 |
positive regulation of interleukin-6 production |
| Biological Process |
GO:0006970 |
response to osmotic stress |
| Biological Process |
GO:0051403 |
stress-activated MAPK cascade |
Reference
PMID: N/A