Search Results
Overview
| Uniprot ID | O15265 |
|---|---|
| Protein Name | Ataxin-7 |
| Gene Name | ATXN7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 858 | SKPTKVAKVPAVNNV |
Function
Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099)
Protein Sequence
10
MSERAADDVR
20
GEPRRAAAAA
30
GGAAAAAARQ
40
QQQQQQQQQP
50
PPPQPQRQQH
60
PPPPPRRTRP
70
EDGGPGAAST
80
SAAAMATVGE
90
RRPLPSPEVM
100
LGQSWNLWVE
110
ASKLPGKDGT
120
ELDESFKEFG
130
KNREVMGLCR
140
EDMPIFGFCP
150
AHDDFYLVVC
160
NDCNQVVKPQ
170
AFQSHYERRH
180
SSSSKPPLAV
190
PPTSVFSFFP
200
SLSKSKGGSA
210
SGSNRSSSGG
220
VLSASSSSSK
230
LLKSPKEKLQ
240
LRGNTRPMHP
250
IQQSRVPHGR
260
IMTPSVKVEK
270
IHPKMDGTLL
280
KSAVGPTCPA
290
TVSSLVKPGL
300
NCPSIPKPTL
310
PSPGQILNGK
320
GLPAPPTLEK
330
KPEDNSNNRK
340
FLNKRLSERE
350
FDPDIHCGVI
360
DLDTKKPCTR
370
SLTCKTHSLT
380
QRRAVQGRRK
390
RFDVLLAEHK
400
NKTREKELIR
410
HPDSQQPPQP
420
LRDPHPAPPR
430
TSQEPHQNPH
440
GVIPSESKPF
450
VASKPKPHTP
460
SLPRPPGCPA
470
QQGGSAPIDP
480
PPVHESPHPP
490
LPATEPASRL
500
SSEEGEGDDK
510
EESVEKLDCH
520
YSGHHPQPAS
530
FCTFGSRQIG
540
RGYYVFDSRW
550
NRLRCALNLM
560
VEKHLNAQLW
570
KKIPPVPSTT
580
SPISTRIPHR
590
TNSVPTSQCG
600
VSYLAAATVS
610
TSPVLLSSTC
620
ISPNSKSVPA
630
HGTTLNAQPA
640
ASGAMDPVCS
650
MQSRQVSSSS
660
SSPSTPSGLS
670
SVPSSPMSRK
680
PQKLKSSKSL
690
RPKESSGNST
700
NCQNASSSTS
710
GGSGKKRKNS
720
SPLLVHSSSS
730
SSSSSSSSHS
740
MESFRKNCVA
750
HSGPPYPSTV
760
TSSHSIGLNC
770
VTNKANAVNV
780
RHDQSGRGPP
790
TGSPAESIKR
800
MSVMVNSSDS
810
TLSLGPFIHQ
820
SNELPVNSHG
830
SFSHSHTPLD
840
KLIGKKRKCS
850
PSSSSINNSS
860
SKPTKVAKVP
870
AVNNVHMKHT
880
GTIPGAQGLM
890
NSSLLHQPKA
RP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0007026 | negative regulation of microtubule depolymerization |
| Biological Process | GO:0006997 | nucleus organization |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006282 | regulation of DNA repair |
| Biological Process | GO:0043484 | regulation of RNA splicing |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007601 | visual perception |
Reference
PMID: N/A