Search Results
Overview
| Uniprot ID | O15344 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase Midline-1 |
| Gene Name | MID1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | SERYDKLKQNLESNL |
Function
Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination
Protein Sequence
10
METLESELTC
20
PICLELFEDP
30
LLLPCAHSLC
40
FNCAHRILVS
50
HCATNESVES
60
ITAFQCPTCR
70
HVITLSQRGL
80
DGLKRNVTLQ
90
NIIDRFQKAS
100
VSGPNSPSET
110
RRERAFDANT
120
MTSAEKVLCQ
130
FCDQDPAQDA
140
VKTCVTCEVS
150
YCDECLKATH
160
PNKKPFTGHR
170
LIEPIPDSHI
180
RGLMCLEHED
190
EKVNMYCVTD
200
DQLICALCKL
210
VGRHRDHQVA
220
ALSERYDKLK
230
QNLESNLTNL
240
IKRNTELETL
250
LAKLIQTCQH
260
VEVNASRQEA
270
KLTEECDLLI
280
EIIQQRRQII
290
GTKIKEGKVM
300
RLRKLAQQIA
310
NCKQCIERSA
320
SLISQAEHSL
330
KENDHARFLQ
340
TAKNITERVS
350
MATASSQVLI
360
PEINLNDTFD
370
TFALDFSREK
380
KLLECLDYLT
390
APNPPTIREE
400
LCTASYDTIT
410
VHWTSDDEFS
420
VVSYELQYTI
430
FTGQANVVSL
440
CNSADSWMIV
450
PNIKQNHYTV
460
HGLQSGTKYI
470
FMVKAINQAG
480
SRSSEPGKLK
490
TNSQPFKLDP
500
KSAHRKLKVS
510
HDNLTVERDE
520
SSSKKSHTPE
530
RFTSQGSYGV
540
AGNVFIDSGR
550
HYWEVVISGS
560
TWYAIGLAYK
570
SAPKHEWIGK
580
NSASWALCRC
590
NNNWVVRHNS
600
KEIPIEPAPH
610
LRRVGILLDY
620
DNGSIAFYDA
630
LNSIHLYTFD
640
VAFAQPVCPT
650
FTVWNKCLTI
660
ITGLPIPDHL
DCTEQLP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0007389 | pattern specification process |
| Biological Process | GO:0032874 | positive regulation of stress-activated MAPK cascade |
| Biological Process | GO:0035372 | protein localization to microtubule |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.