Search Results

Overview

Uniprot IDO15355
Protein NameProtein phosphatase 1G
Gene NamePPM1G
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
166 RYGQNCHKGPPHSKS
172 HKGPPHSKSGGGTGE
209 QENGPTAKAYTGFSS
247 SCSSASDKLPRVAKS
519 ELQPESGKRKLEEVL
521 QPESGKRKLEEVLST
540 ENGNSDKKKKAKRD*

Function

No function data available.

Protein Sequence

10 MGAYLSQPNT 20 VKCSGDGVGA 30 PRLPLPYGFS 40 AMQGWRVSME 50 DAHNCIPELD 60 SETAMFSVYD 70 GHGGEEVALY 80 CAKYLPDIIK 90 DQKAYKEGKL 100 QKALEDAFLA 110 IDAKLTTEEV 120 IKELAQIAGR 130 PTEDEDEKEK 140 VADEDDVDNE 150 EAALLHEEAT 160 MTIEELLTRY 170 GQNCHKGPPH 180 SKSGGGTGEE 190 PGSQGLNGEA 200 GPEDSTRETP 210 SQENGPTAKA 220 YTGFSSNSER 230 GTEAGQVGEP 240 GIPTGEAGPS 250 CSSASDKLPR 260 VAKSKFFEDS 270 EDESDEAEEE 280 EEDSEECSEE 290 EDGYSSEEAE 300 NEEDEDDTEE 310 AEEDDEEEEE 320 EMMVPGMEGK 330 EEPGSDSGTT 340 AVVALIRGKQ 350 LIVANAGDSR 360 CVVSEAGKAL 370 DMSYDHKPED 380 EVELARIKNA 390 GGKVTMDGRV 400 NGGLNLSRAI 410 GDHFYKRNKN 420 LPPEEQMISA 430 LPDIKVLTLT 440 DDHEFMVIAC 450 DGIWNVMSSQ 460 EVVDFIQSKI 470 SQRDENGELR 480 LLSSIVEELL 490 DQCLAPDTSG 500 DGTGCDNMTC 510 IIICFKPRNT 520 AELQPESGKR 530 KLEEVLSTEG 540 AEENGNSDKK KKAKRD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004722 protein serine/threonine phosphatase activity
Biological Process GO:0035970 peptidyl-threonine dephosphorylation
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0007165 signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.