Search Results

Overview

Uniprot IDO15381
Protein NameNuclear valosin-containing protein-like
Gene NameNVL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
129 SLLSLYRKGNPDSVS
156 STPRISSKTGSIPLK
218 SLLESDMKRKGKLKN
28 LTSNKCGKYVDIGVL
85 LEDEHLAKRARQGEE

Function

Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693)

Protein Sequence

10 MKPRPAGFVD 20 NKLKQRVIQY 30 LTSNKCGKYV 40 DIGVLASDLQ 50 RVYSIDYGRR 60 KRNAFRIQVE 70 KVFSIISSEK 80 ELKNLTELED 90 EHLAKRARQG 100 EEDNEYTESY 110 SDDDSSMEDY 120 PDPQSANHMN 130 SSLLSLYRKG 140 NPDSVSNTPE 150 MEQRETTSST 160 PRISSKTGSI 170 PLKTPAKDSE 180 GGWFIDKTPS 190 VKKDSFFLDL 200 SCEKSNPKKP 210 ITEIQDSKDS 220 SLLESDMKRK 230 GKLKNKGSKR 240 KKEDLQEVDG 250 EIEAVLQKKA 260 KARGLEFQIS 270 NVKFEDVGGN 280 DMTLKEVCKM 290 LIHMRHPEVY 300 HHLGVVPPRG 310 VLLHGPPGCG 320 KTLLAHAIAG 330 ELDLPILKVA 340 APEIVSGVSG 350 ESEQKLRELF 360 EQAVSNAPCI 370 IFIDEIDAIT 380 PKREVASKDM 390 ERRIVAQLLT 400 CMDDLNNVAA 410 TARVLVIGAT 420 NRPDSLDPAL 430 RRAGRFDREI 440 CLGIPDEASR 450 ERILQTLCRK 460 LRLPQAFDFC 470 HLAHLTPGFV 480 GADLMALCRE 490 AAMCAVNRVL 500 MKLQEQQKKN 510 PEMEDLPSKG 520 VQEERLGTEP 530 TSETQDELQR 540 LLGLLRDQDP 550 LSEEQMQGLC 560 IELNDFIVAL 570 SSVQPSAKRE 580 GFVTVPNVTW 590 ADIGALEDIR 600 EELTMAILAP 610 VRNPDQFKAL 620 GLVTPAGVLL 630 AGPPGCGKTL 640 LAKAVANESG 650 LNFISVKGPE 660 LLNMYVGESE 670 RAVRQVFQRA 680 KNSAPCVIFF 690 DEVDALCPRR 700 SDRETGASVR 710 VVNQLLTEMD 720 GLEARQQVFI 730 MAATNRPDII 740 DPAILRPGRL 750 DKTLFVGLPP 760 PADRLAILKT 770 ITKNGTKPPL 780 DADVNLEAIA 790 GDLRCDCYTG 800 ADLSALVREA 810 SICALRQEMA 820 RQKSGNEKGE 830 LKVSHKHFEE 840 AFKKVRSSIS 850 KKDQIMYERL QESLSR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005697 telomerase holoenzyme complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:1990275 preribosome binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0032206 positive regulation of telomere maintenance
Biological Process GO:1904749 regulation of protein localization to nucleolus
Biological Process GO:0042273 ribosomal large subunit biogenesis
Biological Process GO:0042254 ribosome biogenesis
Biological Process GO:0006364 rRNA processing
Biological Process GO:1905323 telomerase holoenzyme complex assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.