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Overview

Uniprot ID	O15397
Protein Name	Importin-8
Gene Name	IPO8
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
17	LKGTIDPKLRIAAEN

Function

Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382). In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable)

Protein Sequence

10 MDLNRIIQAL 20 KGTIDPKLRI 30 AAENELNQSY 40 KIINFAPSLL 50 RIIVSDHVEF 60 PVRQAAAIYL 70 KNMVTQYWPD 80 REPPPGEAIF 90 PFNIHENDRQ 100 QIRDNIVEGI 110 IRSPDLVRVQ 120 LTMCLRAIIK 130 HDFPGHWPGV 140 VDKIDYYLQS 150 QSSASWLGSL 160 LCLYQLVKTY 170 EYKKAEEREP 180 LIIAMQIFLP 190 RIQQQIVQLL 200 PDSSYYSVLL 210 QKQILKIFYA 220 LVQYALPLQL 230 VNNQTMTTWM 240 EIFRTIIDRT 250 VPPETLHIDE 260 DDRPELVWWK 270 CKKWALHIVA 280 RLFERYGSPG 290 NVTKEYFEFS 300 EFFLKTYAVG 310 IQQVLLKILD 320 QYRQKEYVAP 330 RVLQQAFNYL 340 NQGVVHSITW 350 KQMKPHIQNI 360 SEDVIFSVMC 370 YKDEDEELWQ 380 EDPYEYIRMK 390 FDIFEDYASP 400 TTAAQTLLYT 410 AAKKRKEVLP 420 KMMAFCYQIL 430 TDPNFDPRKK 440 DGALHVIGSL 450 AEILLKKSLF 460 KDQMELFLQN 470 HVFPLLLSNL 480 GYLRARSCWV 490 LHAFSSLKFH 500 NELNLRNAVE 510 LAKKSLIEDK 520 EMPVKVEAAL 530 ALQSLISNQI 540 QAKEYMKPHV 550 RPIMQELLHI 560 VRETENDDVT 570 NVIQKMICEY 580 SQEVASIAVD 590 MTQHLAEIFG 600 KVLQSDEYEE 610 VEDKTVMAMG 620 ILHTIDTILT 630 VVEDHKEITQ 640 QLENICLRII 650 DLVLQKHVIE 660 FYEEILSLAY 670 SLTCHSISPQ 680 MWQLLGILYE 690 VFQQDCFEYF 700 TDMMPLLHNY 710 VTIDTDTLLS 720 NAKHLEILFT 730 MCRKVLCGDA 740 GEDAECHAAK 750 LLEVIILQCK 760 GRGIDQCIPL 770 FVQLVLERLT 780 RGVKTSELRT 790 MCLQVAIAAL 800 YYNPDLLLHT 810 LERIQLPHNP 820 GPITVQFINQ 830 WMNDTDCFLG 840 HHDRKMCIIG 850 LSILLELQNR 860 PPAVDAVVGQ 870 IVPSILFLFL 880 GLKQVCATRQ 890 LVNREDRSKA 900 EKADMEENEE 910 ISSDEEETNV 920 TAQAMQSNNG 930 RGEDEEEEDD 940 DWDEEVLEET 950 ALEGFSTPLD 960 LDNSVDEYQF 970 FTQALITVQS 980 RDAAWYQLLM 990 APLSEDQRTA 1000 LQEVYTLAEH 1010 RRTVAEAKKK 1020 IEQQGGFTFE 1030 NKGVLSAFNF GTVPSNN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0061608	nuclear import signal receptor activity
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0007165	signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.