Search Results
Overview
| Uniprot ID | O15409 |
|---|---|
| Protein Name | Forkhead box protein P2 |
| Gene Name | FOXP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 587 | YQKRRSQKITGSPTL |
Function
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language
Protein Sequence
10
MMQESATETI
20
SNSSMNQNGM
30
STLSSQLDAG
40
SRDGRSSGDT
50
SSEVSTVELL
60
HLQQQQALQA
70
ARQLLLQQQT
80
SGLKSPKSSD
90
KQRPLQVPVS
100
VAMMTPQVIT
110
PQQMQQILQQ
120
QVLSPQQLQA
130
LLQQQQAVML
140
QQQQLQEFYK
150
KQQEQLHLQL
160
LQQQQQQQQQ
170
QQQQQQQQQQ
180
QQQQQQQQQQ
190
QQQQQQQQQQ
200
QHPGKQAKEQ
210
QQQQQQQQQL
220
AAQQLVFQQQ
230
LLQMQQLQQQ
240
QHLLSLQRQG
250
LISIPPGQAA
260
LPVQSLPQAG
270
LSPAEIQQLW
280
KEVTGVHSME
290
DNGIKHGGLD
300
LTTNNSSSTT
310
SSNTSKASPP
320
ITHHSIVNGQ
330
SSVLSARRDS
340
SSHEETGASH
350
TLYGHGVCKW
360
PGCESICEDF
370
GQFLKHLNNE
380
HALDDRSTAQ
390
CRVQMQVVQQ
400
LEIQLSKERE
410
RLQAMMTHLH
420
MRPSEPKPSP
430
KPLNLVSSVT
440
MSKNMLETSP
450
QSLPQTPTTP
460
TAPVTPITQG
470
PSVITPASVP
480
NVGAIRRRHS
490
DKYNIPMSSE
500
IAPNYEFYKN
510
ADVRPPFTYA
520
TLIRQAIMES
530
SDRQLTLNEI
540
YSWFTRTFAY
550
FRRNAATWKN
560
AVRHNLSLHK
570
CFVRVENVKG
580
AVWTVDEVEY
590
QKRRSQKITG
600
SPTLVKNIPT
610
SLGYGAALNA
620
SLQAALAESS
630
LPLLSNPGLI
640
NNASSGLLQA
650
VHEDLNGSLD
660
HIDSNGNSSP
670
GCSPQPHIHS
680
IHVKEEPVIA
690
EDEDCPMSLV
700
TTANHSPELE
710
DDREIEEEPL
SEDLE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:0001221 | transcription coregulator binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0021757 | caudate nucleus development |
| Biological Process | GO:0021702 | cerebellar Purkinje cell differentiation |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0021758 | putamen development |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
| Biological Process | GO:0048745 | smooth muscle tissue development |
| Biological Process | GO:0071625 | vocalization behavior |
Reference
PMID: N/A