Search Results

Overview

Uniprot IDO15417
Protein NameTrinucleotide repeat-containing gene 18 protein
Gene NameTNRC18
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
272 FLAESKTKNAALQPS
492 PAAQQAAKLFGLEPG
609 VRPGGCGKKSPFGGL
610 RPGGCGKKSPFGGLG

Function

Chromatin reader involved in the silencing of endogenous retroviruses (ERV) class-I elements, such as LTR12 (PubMed:37938770). Specifically binds histone H3 trimethylated at 'Lys-9' (H3K9me3) deposited by SETB1 at class-I ERV and directly mediates recruitment of corepressor complexes, such as Sin3-type and N-Cor complexes, leading to ERV silencing (PubMed:37938770)

Protein Sequence

10 MDGRDFGPQR 20 SVHGPPPPLL 30 SGLAMDSHRV 40 GAATAGRLPA 50 SGLPGPLPPG 60 KYMAGLNLHP 70 HPGEAFLGSF 80 VASGMGPSAS 90 SHGSPVPLPS 100 DLSFRSPTPS 110 NLPMVQLWAA 120 HAHEGFSHLP 130 SGLYPSYLHL 140 NHLEPPSSGS 150 PLLSQLGQPS 160 IFDTQKGQGP 170 GGDGFYLPTA 180 GAPGSLHSHA 190 PSARTPGGGH 200 SSGAPAKGSS 210 SRDGPAKERA 220 GRGGEPPPLF 230 GKKDPRARGE 240 EASGPRGVVD 250 LTQEARAEGR 260 QDRGPPRLAE 270 RLSPFLAESK 280 TKNAALQPSV 290 LTMCNGGAGD 300 VGLPALVAEA 310 GRGGAKEAAR 320 QDEGARLLRR 330 TETLLPGPRP 340 CPSPLPPPPA 350 PPKGPPAPPA 360 ATPAGVYTVF 370 REQGREHRVV 380 APTFVPSVEA 390 FDERPGPIQI 400 ASQARDARAR 410 EREAGRPGVL 420 QAPPGSPRPL 430 DRPEGLREKN 440 SVIRSLKRPP 450 PADAPTVRAT 460 RASPDPRAYV 470 PAKELLKPEA 480 DPRPCERAPR 490 GPAGPAAQQA 500 AKLFGLEPGR 510 PPPTGPEHKW 520 KPFELGNFAA 530 TQMAVLAAQH 540 HHSRAEEEAA 550 VVAASSSKKA 560 YLDPGAVLPR 570 SAATCGRPVA 580 DMHSAAHGSG 590 EASAMQSLIK 600 YSGSFARDAV 610 AVRPGGCGKK 620 SPFGGLGTMK 630 PEPAPTSAGA 640 SRAQARLPHS 650 GGPAAGGGRQ 660 LKRDPERPES 670 AKAFGREGSG 680 AQGEAEVRHP 690 PVGIAVAVAR 700 QKDSGGSGRL 710 GPGLVDQERS 720 LSLSNVKGHG 730 RADEDCVDDR 740 ARHREERLLG 750 ARLDRDQEKL 760 LRESKELADL 770 ARLHPTSCAP 780 NGLNPNLMVT 790 GGPALAGSGR 800 WSADPAAHLA 810 THPWLPRSGN 820 ASMWLAGHPY 830 GLGPPSLHQG 840 MAPAFPPGLG 850 GSLPSAYQFV 860 RDPQSGQLVV 870 IPSDHLPHFA 880 ELMERATVPP 890 LWPALYPPGR 900 SPLHHAQQLQ 910 LFSQQHFLRQ 920 QEFLYLQQQA 930 AQALELQRSA 940 QLVQERLKAQ 950 EHRAEMEEKG 960 SKRGLEAAGK 970 AGLATAGPGL 980 LPRKPPGLAA 990 GPAGTYGKAV 1000 SPPPSPRASP 1010 VAALKAKVIQ 1020 KLEDVSKPPA 1030 YAYPATPSSH 1040 PTSPPPASPP 1050 PTPGITRKEE 1060 APENVVEKKD 1070 LELEKEAPSP 1080 FQALFSDIPP 1090 RYPFQALPPH 1100 YGRPYPFLLQ 1110 PTAAADADGL 1120 APDVPLPADG 1130 PERLALSPED 1140 KPIRLSPSKI 1150 TEPLREGPEE 1160 EPLAEREVKA 1170 EVEDMDEGPT 1180 ELPPLESPLP 1190 LPAAEAMATP 1200 SPAGGCGGGL 1210 LEAQALSATG 1220 QSCAEPSECP 1230 DFVEGPEPRV 1240 DSPGRTEPCT 1250 AALDLGVQLT 1260 PETLVEAKEE 1270 PVEVPVAVPV 1280 VEAVPEEGLA 1290 QVAPSESQPT 1300 LEMSDCDVPA 1310 GEGQCPSLEP 1320 QEAVPVLGST 1330 CFLEEASSDQ 1340 FLPSLEDPLA 1350 GMNALAAAAE 1360 LPQARPLPSP 1370 GAAGAQALEK 1380 LEAAESLVLE 1390 QSFLHGITLL 1400 SEIAELELER 1410 RSQEMGGAER 1420 ALVARPSLES 1430 LLAAGSHMLR 1440 EVLDGPVVDP 1450 LKNLRLPREL 1460 KPNKKYSWMR 1470 KKEERMYAMK 1480 SSLEDMDALE 1490 LDFRMRLAEV 1500 QRQYKEKQRE 1510 LVKLQRRRDS 1520 EDRREEPHRS 1530 LARRGPGRPR 1540 KRTHAPSALS 1550 PPRKRGKSGH 1560 SSGKLSSKSL 1570 LTSDDYELGA 1580 GIRKRHKGSE 1590 EEHDALIGMG 1600 KARGRNQTWD 1610 EHEASSDFIS 1620 QLKIKKKKMA 1630 SDQEQLASKL 1640 DKALSLTKQD 1650 KLKSPFKFSD 1660 SAGGKSKTSG 1670 GCGRYLTPYD 1680 SLLGKNRKAL 1690 AKGLGLSLKS 1700 SREGKHKRAA 1710 KTRKMEVGFK 1720 ARGQPKSAHS 1730 PFASEVSSYS 1740 YNTDSEEDEE 1750 FLKDEWPAQG 1760 PSSSKLTPSL 1770 LCSMVAKNSK 1780 AAGGPKLTKR 1790 GLAAPRTLKP 1800 KPATSRKQPF 1810 CLLLREAEAR 1820 SSFSDSSEES 1830 FDQDESSEEE 1840 DEEEELEEED 1850 EASGGGYRLG 1860 ARERALSPGL 1870 EESGLGLLAR 1880 FAASALPSPT 1890 VGPSLSVVQL 1900 EAKQKARKKE 1910 ERQSLLGTEF 1920 EYTDSESEVK 1930 VRKRSPAGLL 1940 RPKKGLGEPG 1950 PSLAAPTPGA 1960 RGPDPSSPDK 1970 AKLAVEKGRK 1980 ARKLRGPKEP 1990 GFEAGPEASD 2000 DDLWTRRRSE 2010 RIFLHDASAA 2020 APAPVSTAPA 2030 TKTSRCAKGG 2040 PLSPRKDAGR 2050 AKDRKDPRKK 2060 KKGKEAGPGA 2070 GLPPPRAPAL 2080 PSEARAPHAS 2090 SLTAAKRSKA 2100 KAKGKEVKKE 2110 NRGKGGAVSK 2120 LMESMAAEED 2130 FEPNQDSSFS 2140 EDEHLPRGGA 2150 VERPLTPAPR 2160 SCIIDKDELK 2170 DGLRVLIPMD 2180 DKLLYAGHVQ 2190 TVHSPDIYRV 2200 VVEGERGNRP 2210 HIYCLEQLLQ 2220 EAIIDVRPAS 2230 TRFLPQGTRI 2240 AAYWSQQYRC 2250 LYPGTVVRGL 2260 LDLEDDGDLI 2270 TVEFDDGDTG 2280 RIPLSHIRLL 2290 PPDYKIQCAE 2300 PSPALLVPSA 2310 KRRSRKTSKD 2320 TGEGKDGGTA 2330 GSEEPGAKAR 2340 GRGRKPSAKA 2350 KGDRAATLEE 2360 GNPTDEVPST 2370 PLALEPSSTP 2380 GSKKSPPEPV 2390 DKRAKAPKAR 2400 PAPPQPSPAP 2410 PAFTSCPAPE 2420 PFAELPAPAT 2430 SLAPAPLITM 2440 PATRPKPKKA 2450 RAAEESGAKG 2460 PRRPGEEAEL 2470 LVKLDHEGVT 2480 SPKSKKAKEA 2490 LLLREDPGAG 2500 GWQEPKSLLS 2510 LGSYPPAAGS 2520 SEPKAPWPKA 2530 TDGDLAQEPG 2540 PGLTFEDSGN 2550 PKSPDKAQAE 2560 QDGAEESESS 2570 SSSSSGSSSS 2580 SSSSSSSGSE 2590 TEGEEEGDKN 2600 GDGGCGTGGR 2610 NCSAASSRAA 2620 SPASSSSSSS 2630 SSSSSSSSSS 2640 SSSSSSSSSS 2650 SSSSSSSSSS 2660 SSSSSSSSSS 2670 SSSSSSSSSS 2680 STTDEDSSCS 2690 SDDEAAPAPT 2700 AGPSAQAALP 2710 TKATKQAGKA 2720 RPSAHSPGKK 2730 TPAPQPQAPP 2740 PQPTQPLQPK 2750 AQAGAKSRPK 2760 KREGVHLPTT 2770 KELAKRQRLP 2780 SVENRPKIAA 2790 FLPARQLWKW 2800 FGKPTQRRGM 2810 KGKARKLFYK 2820 AIVRGKEMIR 2830 IGDCAVFLSA 2840 GRPNLPYIGR 2850 IQSMWESWGN 2860 NMVVRVKWFY 2870 HPEETSPGKQ 2880 FHQGQHWDQK 2890 SSRSLPAALR 2900 VSSQRKDFME 2910 RALYQSSHVD 2920 ENDVQTVSHK 2930 CLVVGLEQYE 2940 QMLKTKKYQD 2950 SEGLYYLAGT 2960 YEPTTGMIFS TDGVPVLC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0140463 chromatin-protein adaptor activity
Molecular Function GO:0062072 histone H3K9me2/3 reader activity
Biological Process GO:0071168 protein localization to chromatin
Biological Process GO:0141005 transposable element silencing by heterochromatin formation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.