Overview
| Uniprot ID | O15431 |
|---|
| Protein Name | High affinity copper uptake protein 1 |
|---|
| Gene Name | SLC31A1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 96 |
ARESLLRKSQVSIRY |
Function
Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane (PubMed:11734551, PubMed:16135512, PubMed:17525160, PubMed:19740744, PubMed:20451502, PubMed:20569931, PubMed:23658018) and delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels (PubMed:11734551, PubMed:16135512, PubMed:17525160, PubMed:19740744, PubMed:20451502, PubMed:20569931, PubMed:23658018, PubMed:26745413). May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption (By similarity). The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity (PubMed:11734551). Also mediates the uptake of silver(1+) (PubMed:20569931). May function in the influx of the platinum-containing chemotherapeutic agents (PubMed:20451502, PubMed:20569931). The platinum-containing chemotherapeutic agents uptake is saturable (By similarity). In vitro, mediates the transport of cadmium(2+) into cells (PubMed:33294387). Also participates in the first step of copper(2+) acquisition by cells through a direct transfer of copper(2+) from copper(2+) carriers in blood, such as ALB to the N-terminal domain of SLC31A1, leading to copper(2+) reduction and probably followed by copper(1+) stabilization (PubMed:30489586). In addition, functions as a redox sensor to promote angiogenesis in endothelial cells, in a copper(1+) transport independent manner, by transmitting the VEGF-induced ROS signal through a sulfenylation at Cys-189 leadin g to a subsequent disulfide bond formation between SLC31A1 and KDR (PubMed:35027734). The SLC31A1-KDR complex is then co-internalized to early endosomes, driving a sustained VEGFR2 signaling (PubMed:35027734)
Protein Sequence
10
MDHSHHMGMS
20
YMDSNSTMQP
30
SHHHPTTSAS
40
HSHGGGDSSM
50
MMMPMTFYFG
60
FKNVELLFSG
70
LVINTAGEMA
80
GAFVAVFLLA
90
MFYEGLKIAR
100
ESLLRKSQVS
110
IRYNSMPVPG
120
PNGTILMETH
130
KTVGQQMLSF
140
PHLLQTVLHI
150
IQVVISYFLM
160
LIFMTYNGYL
170
CIAVAAGAGT
180
GYFLFSWKKA
190
VVVDITEHCH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0014704 |
intercalated disc |
| Cellular Component |
GO:0031902 |
late endosome membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Molecular Function |
GO:0005507 |
copper ion binding |
| Molecular Function |
GO:0005375 |
copper ion transmembrane transporter activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0015080 |
silver ion transmembrane transporter activity |
| Molecular Function |
GO:0042910 |
xenobiotic transmembrane transporter activity |
| Biological Process |
GO:0001525 |
angiogenesis |
| Biological Process |
GO:0015677 |
copper ion import |
| Biological Process |
GO:0035434 |
copper ion transmembrane transport |
| Biological Process |
GO:0006825 |
copper ion transport |
| Biological Process |
GO:0030001 |
metal ion transport |
| Biological Process |
GO:0015679 |
plasma membrane copper ion transport |
| Biological Process |
GO:0051259 |
protein complex oligomerization |
| Biological Process |
GO:1902601 |
silver ion transmembrane transport |
| Biological Process |
GO:0036324 |
vascular endothelial growth factor receptor-2 signaling pathway |
| Biological Process |
GO:0042908 |
xenobiotic transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.