Search Results

Overview

Uniprot ID	O15446
Protein Name	DNA-directed RNA polymerase I subunit RPA34
Gene Name	POLR1G
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
174	PNLLTSGKKKKEMQV
175	NLLTSGKKKKEMQVT
328	AIPLPPTKKRKKEKG
329	IPLPPTKKRKKEKGQ
70	LSGSQIVKGKLAGKR

Function

Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation

Protein Sequence

10 MEEPQAGDAA 20 RFSCPPNFTA 30 KPPASESPRF 40 SLEALTGPDT 50 ELWLIQAPAD 60 FAPECFNGRH 70 VPLSGSQIVK 80 GKLAGKRHRY 90 RVLSSCPQAG 100 EATLLAPSTE 110 AGGGLTCASA 120 PQGTLRILEG 130 PQQSLSGSPL 140 QPIPASPPPQ 150 IPPGLRPRFC 160 AFGGNPPVTG 170 PRSALAPNLL 180 TSGKKKKEMQ 190 VTEAPVTQEA 200 VNGHGALEVD 210 MALGSPEMDV 220 RKKKKKKNQQ 230 LKEPEAAGPV 240 GTEPTVETLE 250 PLGVLFPSTT 260 KKRKKPKGKE 270 TFEPEDKTVK 280 QEQINTEPLE 290 DTVLSPTKKR 300 KRQKGTEGME 310 PEEGVTVESQ 320 PQVKVEPLEE 330 AIPLPPTKKR 340 KKEKGQMAMM 350 EPGTEAMEPV 360 EPEMKPLESP 370 GGTMAPQQPE 380 GAKPQAQAAL 390 AAPKKKTKKE 400 KQQDATVEPE 410 TEVVGPELPD 420 DLEPQAAPTS 430 TKKKKKKKER 440 GHTVTEPIQP 450 LEPELPGEGQ 460 PEARATPGST 470 KKRKKQSQES 480 RMPETVPQEE 490 MPGPPLNSES 500 GEEAPTGRDK 510 KRKQQQQQPV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0001650	fibrillar center
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005736	RNA polymerase I complex
Cellular Component	GO:0000120	RNA polymerase I transcription regulator complex
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway
Biological Process	GO:0042790	nucleolar large rRNA transcription by RNA polymerase I
Biological Process	GO:0009303	rRNA transcription
Biological Process	GO:0006363	termination of RNA polymerase I transcription
Biological Process	GO:0006362	transcription elongation by RNA polymerase I
Biological Process	GO:0006361	transcription initiation at RNA polymerase I promoter

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.