Search Results
Overview
| Uniprot ID | O15498 |
|---|---|
| Protein Name | Synaptobrevin homolog YKT6 |
| Gene Name | YKT6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | READPMTKVQAELDE |
Function
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment (PubMed:9211930, PubMed:15215310). Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5 (By similarity). Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5 (PubMed:15215310). Has a S-palmitoyl transferase activity (PubMed:15479160, PubMed:15044687). Essential for the structural and functional organization of the Golgi apparatus (PubMed:32128853)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0030133 | transport vesicle |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0019706 | protein-cysteine S-palmitoyltransferase activity |
| Molecular Function | GO:0005484 | SNAP receptor activity |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0042147 | retrograde transport, endosome to Golgi |
| Biological Process | GO:0006904 | vesicle docking involved in exocytosis |
| Biological Process | GO:0006906 | vesicle fusion |
| Biological Process | GO:0006903 | vesicle targeting |
| Cellular Component | GO:0097440 | apical dendrite |
| Cellular Component | GO:0000421 | autophagosome membrane |
| Cellular Component | GO:0097441 | basal dendrite |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.