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Overview

Uniprot IDO15504
Protein NameNucleoporin NUP42
Gene NameNUP42
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
65 IQPSSFSKSTPWGGS

Function

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm

Protein Sequence

10 MAICQFFLQG 20 RCRFGDRCWN 30 EHPGARGAGG 40 GRQQPQQQPS 50 GNNRRGWNTT 60 SQRYSNVIQP 70 SSFSKSTPWG 80 GSRDQEKPYF 90 SSFDSGASTN 100 RKEGFGLSEN 110 PFASLSPDEQ 120 KDEKKLLEGI 130 VKDMEVWESS 140 GQWMFSVYSP 150 VKKKPNISGF 160 TDISPEELRL 170 EYHNFLTSNN 180 LQSYLNSVQR 190 LINQWRNRVN 200 ELKSLNISTK 210 VALLSDVKDG 220 VNQAAPAFGF 230 GSSQAATFMS 240 PGFPVNNSSS 250 DNAQNFSFKT 260 NSGFAAASSG 270 SPAGFGSSPA 280 FGAAASTSSG 290 ISTSAPAFGF 300 GKPEVTSAAS 310 FSFKSPAASS 320 FGSPGFSGLP 330 ASLATGPVRA 340 PVAPAFGGGS 350 SVAGFGSPGS 360 HSHTAFSKPS 370 SDTFGNSSIS 380 TSLSASSSII 390 ATDNVLFTPR 400 DKLTVEELEQ 410 FQSKKFTLGK 420 IPLKPPPLEL LNV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005049 nuclear export signal receptor activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051028 mRNA transport
Biological Process GO:0006913 nucleocytoplasmic transport
Biological Process GO:0006611 protein export from nucleus

Reference

[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.