Search Results
Overview
| Uniprot ID | O15519 |
|---|---|
| Protein Name | CASP8 and FADD-like apoptosis regulator |
| Gene Name | CFLAR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | SSLIFLMKDYMGRGK |
| 124 | KDYMGRGKISKEKSF |
Function
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells (PubMed:31046799). Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity
Protein Sequence
10
MSAEVIHQVE
20
EALDTDEKEM
30
LLFLCRDVAI
40
DVVPPNVRDL
50
LDILRERGKL
60
SVGDLAELLY
70
RVRRFDLLKR
80
ILKMDRKAVE
90
THLLRNPHLV
100
SDYRVLMAEI
110
GEDLDKSDVS
120
SLIFLMKDYM
130
GRGKISKEKS
140
FLDLVVELEK
150
LNLVAPDQLD
160
LLEKCLKNIH
170
RIDLKTKIQK
180
YKQSVQGAGT
190
SYRNVLQAAI
200
QKSLKDPSNN
210
FRLHNGRSKE
220
QRLKEQLGAQ
230
QEPVKKSIQE
240
SEAFLPQSIP
250
EERYKMKSKP
260
LGICLIIDCI
270
GNETELLRDT
280
FTSLGYEVQK
290
FLHLSMHGIS
300
QILGQFACMP
310
EHRDYDSFVC
320
VLVSRGGSQS
330
VYGVDQTHSG
340
LPLHHIRRMF
350
MGDSCPYLAG
360
KPKMFFIQNY
370
VVSEGQLEDS
380
SLLEVDGPAM
390
KNVEFKAQKR
400
GLCTVHREAD
410
FFWSLCTADM
420
SLLEQSHSSP
430
SLYLQCLSQK
440
LRQERKRPLL
450
DLHIELNGYM
460
YDWNSRVSAK
470
EKYYVWLQHT
480
LRKKLILSYT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031265 | CD95 death-inducing signaling complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031264 | death-inducing signaling complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0097342 | ripoptosome |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:0005123 | death receptor binding |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0071549 | cellular response to dexamethasone stimulus |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0071392 | cellular response to estradiol stimulus |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0071732 | cellular response to nitric oxide |
| Biological Process | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0030225 | macrophage differentiation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| Biological Process | GO:1903845 | negative regulation of cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:1903944 | negative regulation of hepatocyte apoptotic process |
| Biological Process | GO:1901740 | negative regulation of myoblast fusion |
| Biological Process | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:1903055 | positive regulation of extracellular matrix organization |
| Biological Process | GO:0072126 | positive regulation of glomerular mesangial cell proliferation |
| Biological Process | GO:2000347 | positive regulation of hepatocyte proliferation |
| Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0060544 | regulation of necroptotic process |
| Biological Process | GO:0014842 | regulation of skeletal muscle satellite cell proliferation |
| Biological Process | GO:0033574 | response to testosterone |
| Biological Process | GO:0014732 | skeletal muscle atrophy |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
| Biological Process | GO:0043403 | skeletal muscle tissue regeneration |
| Biological Process | GO:0014866 | skeletal myofibril assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.