Search Results

Overview

Uniprot ID	O15523
Protein Name	ATP-dependent RNA helicase DDX3Y
Gene Name	DDX3Y
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
55	ASKGFHDKDSSGWSC
64	SSGWSCSKDKDAYSS
66	GWSCSKDKDAYSSFG

Function

Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity)

Protein Sequence

10 MSHVVVKNDP 20 ELDQQLANLD 30 LNSEKQSGGA 40 STASKGRYIP 50 PHLRNREASK 60 GFHDKDSSGW 70 SCSKDKDAYS 80 SFGSRDSRGK 90 PGYFSERGSG 100 SRGRFDDRGR 110 SDYDGIGNRE 120 RPGFGRFERS 130 GHSRWCDKSV 140 EDDWSKPLPP 150 SERLEQELFS 160 GGNTGINFEK 170 YDDIPVEATG 180 SNCPPHIENF 190 SDIDMGEIIM 200 GNIELTRYTR 210 PTPVQKHAIP 220 IIKGKRDLMA 230 CAQTGSGKTA 240 AFLLPILSQI 250 YTDGPGEALK 260 AVKENGRYGR 270 RKQYPISLVL 280 APTRELAVQI 290 YEEARKFSYR 300 SRVRPCVVYG 310 GADIGQQIRD 320 LERGCHLLVA 330 TPGRLVDMME 340 RGKIGLDFCK 350 YLVLDEADRM 360 LDMGFEPQIR 370 RIVEQDTMPP 380 KGVRHTMMFS 390 ATFPKEIQML 400 ARDFLDEYIF 410 LAVGRVGSTS 420 ENITQKVVWV 430 EDLDKRSFLL 440 DILGATGSDS 450 LTLVFVETKK 460 GADSLEDFLY 470 HEGYACTSIH 480 GDRSQRDREE 490 ALHQFRSGKS 500 PILVATAVAA 510 RGLDISNVRH 520 VINFDLPSDI 530 EEYVHRIGRT 540 GRVGNLGLAT 550 SFFNEKNMNI 560 TKDLLDLLVE 570 AKQEVPSWLE 580 NMAYEHHYKG 590 GSRGRSKSNR 600 FSGGFGARDY 610 RQSSGSSSSG 620 FGASRGSSSR 630 SGGGGYGNSR 640 GFGGGGYGGF 650 YNSDGYGGNY 660 NSQGVDWWGN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0043186	P granule
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003724	RNA helicase activity
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007276	gamete generation
Biological Process	GO:0010629	negative regulation of gene expression

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.