Search Results
Overview
| Uniprot ID | O15533 |
|---|---|
| Protein Name | Tapasin |
| Gene Name | TAPBP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 342 | GPGGRSQKAEGQRWL |
Function
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)
Protein Sequence
10
MKSLSLLLAV
20
ALGLATAVSA
30
GPAVIECWFV
40
EDASGKGLAK
50
RPGALLLRQG
60
PGEPPPRPDL
70
DPELYLSVHD
80
PAGALQAAFR
90
RYPRGAPAPH
100
CEMSRFVPLP
110
ASAKWASGLT
120
PAQNCPRALD
130
GAWLMVSISS
140
PVLSLSSLLR
150
PQPEPQQEPV
160
LITMATVVLT
170
VLTHTPAPRV
180
RLGQDALLDL
190
SFAYMPPTSE
200
AASSLAPGPP
210
PFGLEWRRQH
220
LGKGHLLLAA
230
TPGLNGQMPA
240
AQEGAVAFAA
250
WDDDEPWGPW
260
TGNGTFWLPT
270
VQPFQEGTYL
280
ATIHLPYLQG
290
QVTLELAVYK
300
PPKVSLMPAT
310
LARAAPGEAP
320
PELLCLVSHF
330
YPSGGLEVEW
340
ELRGGPGGRS
350
QKAEGQRWLS
360
ALRHHSDGSV
370
SLSGHLQPPP
380
VTTEQHGARY
390
ACRIHHPSLP
400
ASGRSAEVTL
410
EVAGLSGPSL
420
EDSVGLFLSA
430
FLLLGLFKAL
440
GWAAVYLSTC
KDSKKKAE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0098553 | lumenal side of endoplasmic reticulum membrane |
| Cellular Component | GO:0042824 | MHC class I peptide loading complex |
| Cellular Component | GO:0030670 | phagocytic vesicle membrane |
| Molecular Function | GO:0042288 | MHC class I protein binding |
| Molecular Function | GO:0023024 | MHC class I protein complex binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0042605 | peptide antigen binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0062061 | TAP complex binding |
| Molecular Function | GO:0046978 | TAP1 binding |
| Molecular Function | GO:0046979 | TAP2 binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| Biological Process | GO:0002398 | MHC class Ib protein complex assembly |
| Biological Process | GO:0002502 | peptide antigen assembly with MHC class I protein complex |
| Biological Process | GO:0050823 | peptide antigen stabilization |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0061635 | regulation of protein complex stability |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.