Search Results

Overview

Uniprot IDO35095
Protein NameNeurochondrin
Gene NameNcdn
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
272 LARILGSKLSSWQRN
357 RCEQSLLKEPQKVQL
361 SLLKEPQKVQLVSIM
64 LLVTKAVKAGDIDAK
92 PNRLLTTKEAPDGCP

Function

Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth

Protein Sequence

10 MSCCDLAAAG 20 QLGKAGIMAS 30 DCEPALNQAE 40 SRNPTLERYL 50 GALREAKNDS 60 EQFAALLLVT 70 KAVKAGDIDA 80 KTRRRIFDAV 90 GFTFPNRLLT 100 TKEAPDGCPD 110 HVLRALGVAL 120 LACFCSDPEL 130 ASHPQVLNKI 140 PILCTFLTAR 150 GDPDDAARRS 160 MIDDTYQCLT 170 AVAGTPRGPR 180 HLIAGGTVSA 190 LCQAYLGHGY 200 GFDQALALLV 210 GLLAAAETQC 220 WKEAEPDLLA 230 VLRGLSEDFQ 240 RAEDASKFEL 250 CQLLPLFLPP 260 TTVPPECHRD 270 LQAGLARILG 280 SKLSSWQRNP 290 ALKLAARLAH 300 ACGSDWIPVG 310 SSGSKFLALL 320 VNLACVEVRL 330 ALEETGTEVK 340 EDVVTACYAL 350 MELGIQECTR 360 CEQSLLKEPQ 370 KVQLVSIMKE 380 AIGAVIHYLL 390 RVGPEKQKEP 400 FVFASVRILG 410 AWLAEETSSL 420 RKEVCQLLPF 430 LVRYAKTLYE 440 EAEEASDISQ 450 QVANLAISPT 460 TPGPAWPGDA 470 LRLLLPGWCH 480 LTVEDGPREI 490 LIKEGAPSLL 500 CKYFLQQWEL 510 TSPGHDTSVL 520 PDSVEIGLQT 530 CCHIFLNLVV 540 TAPGLIKRDA 550 CFTSLMNTLM 560 TSLPSLVQQQ 570 GRLLLAANVA 580 TLGLLMARLL 590 STSPALQGTP 600 ASRGFFAAAI 610 LFLSQSHVAR 620 ATPGSDQAVL 630 ALSPDYEGIW 640 ADLQELWFLG 650 MQAFTGCVPL 660 LPWLAPAALR 670 SRWPQELLQL 680 LGSVSPNSVK 690 PEMVAAYQGV 700 LVELARANRL 710 CREAMRLQAG 720 EETASHYRMA ALEQCLSEP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0098794 postsynapse
Biological Process GO:0045453 bone resorption
Biological Process GO:0031175 neuron projection development
Biological Process GO:0048168 regulation of neuronal synaptic plasticity
Biological Process GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.