Search Results
Overview
| Uniprot ID | O35129 |
|---|---|
| Protein Name | Prohibitin-2 |
| Gene Name | Phb2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 244 | MLGEALSKNPGYIKL |
| 262 | RAAQNISKTIATSQN |
| 6 | **MAQNLKDLAGRLP |
| 89 | DIRARPRKISSPTGS |
Function
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus
Protein Sequence
10
MAQNLKDLAG
20
RLPAGPRGMG
30
TALKLLLGAG
40
AVAYGVRESV
50
FTVEGGHRAI
60
FFNRIGGVQQ
70
DTILAEGLHF
80
RIPWFQYPII
90
YDIRARPRKI
100
SSPTGSKDLQ
110
MVNISLRVLS
120
RPNAQELPSM
130
YQRLGLDYEE
140
RVLPSIVNEV
150
LKSVVAKFNA
160
SQLITQRAQV
170
SLLIRRELTE
180
RAKDFSLILD
190
DVAITELSFS
200
REYTAAVEAK
210
QVAQQEAQRA
220
QFLVEKAKQE
230
QRQKIVQAEG
240
EAEAAKMLGE
250
ALSKNPGYIK
260
LRKIRAAQNI
270
SKTIATSQNR
280
IYLTADNLVL
290
NLQDESFTRG
SDSLIKGKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098800 | inner mitochondrial membrane protein complex |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0035632 | mitochondrial prohibitin complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0033218 | amide binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0046625 | sphingolipid binding |
| Biological Process | GO:0140374 | antiviral innate immune response |
| Biological Process | GO:0042113 | B cell activation |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0060749 | mammary gland alveolus development |
| Biological Process | GO:0060744 | mammary gland branching involved in thelarche |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0000423 | mitophagy |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway |
| Biological Process | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0002639 | positive regulation of immunoglobulin production |
| Biological Process | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis |
| Biological Process | GO:1900208 | regulation of cardiolipin metabolic process |
| Biological Process | GO:1904959 | regulation of cytochrome-c oxidase activity |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0039529 | RIG-I signaling pathway |
| Biological Process | GO:0007062 | sister chromatid cohesion |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.