Search Results

Overview

Uniprot IDO35179
Protein NameEndophilin-A1
Gene NameSh3gl2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
12 GLKKQFHKATQKVSE
128 MRELSEVKDSLDMEV
159 REIQHHLKKLEGRRL
171 RRLDFDYKKKRQGKI
177 YKKKRQGKIPDEELR
189 ELRQALEKFDESKEI
20 ATQKVSEKVGGAEGT
34 TKLDDDFKEMERKVD
67 PNPASRAKLSMINTM
76 SMINTMSKIRGQEKG
82 SKIRGQEKGPGYPQA

Function

Implicated in endocytosis (PubMed:11604418, PubMed:16763559). Involved ultrafast endocytosis, by mediating, in a first step, neck formation and in a second step, aids in the removal of clathrin coats from the regenerated vesicles (By similarity). May recruit other proteins to membranes with high curvature (By similarity) (PubMed:11604418, PubMed:16763559). Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (By similarity)

Protein Sequence

10 MSVAGLKKQF 20 HKATQKVSEK 30 VGGAEGTKLD 40 DDFKEMERKV 50 DVTSRAVMEI 60 MTKTIEYLQP 70 NPASRAKLSM 80 INTMSKIRGQ 90 EKGPGYPQAE 100 ALLAEAMLKF 110 GRELGDDCNF 120 GPALGEVGEA 130 MRELSEVKDS 140 LDMEVKQNFI 150 DPLQNLHDKD 160 LREIQHHLKK 170 LEGRRLDFDY 180 KKKRQGKIPD 190 EELRQALEKF 200 DESKEIAESS 210 MFNLLEMDIE 220 QVSQLSALVQ 230 AQLEYHKQAV 240 QILQQVTVRL 250 EERIRQASSQ 260 PRREYQPKPR 270 MSLEFATGDG 280 TQPNGGLSHT 290 GTPKPAGVQM 300 DQPCCRALYD 310 FEPENEGELG 320 FKEGDIITLT 330 NQIDENWYEG 340 MLHGQSGFFP 350 INYVEILVAL PH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098686 hippocampal mossy fiber to CA3 synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0098684 photoreceptor ribbon synapse
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0098793 presynapse
Cellular Component GO:0099523 presynaptic cytosol
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0045202 synapse
Cellular Component GO:0030672 synaptic vesicle membrane
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
Biological Process GO:0097484 dendrite extension
Biological Process GO:0060988 lipid tube assembly
Biological Process GO:0097753 membrane bending
Biological Process GO:0097749 membrane tubulation
Biological Process GO:1905604 negative regulation of blood-brain barrier permeability
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0043409 negative regulation of MAPK cascade
Biological Process GO:0031175 neuron projection development
Biological Process GO:1903527 positive regulation of membrane tubulation
Biological Process GO:0098974 postsynaptic actin cytoskeleton organization
Biological Process GO:2000369 regulation of clathrin-dependent endocytosis
Biological Process GO:0002090 regulation of receptor internalization
Biological Process GO:0048488 synaptic vesicle endocytosis
Biological Process GO:0099050 vesicle scission

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.