Search Results

Overview

Uniprot IDO35244
Protein NamePeroxiredoxin-6
Gene NamePrdx6
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
106 PFPIIDDKDRDLAIL
141 VFIFGPDKKLKLSIL
144 FGPDKKLKLSILYPA
209 FPKGVFTKELPSGKK
215 TKELPSGKKYLRYTP
56 TELGRAAKLAPEFAK
63 KLAPEFAKRNVKLIA

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:15004285). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:15004285, PubMed:17652308, PubMed:8999971). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity)

Protein Sequence

10 MPGGLLLGDE 20 APNFEANTTI 30 GHIRFHDFLG 40 DSWGILFSHP 50 RDFTPVCTTE 60 LGRAAKLAPE 70 FAKRNVKLIA 80 LSIDSVEDHF 90 AWSKDINAYN 100 GAAPTEKLPF 110 PIIDDKDRDL 120 AILLGMLDPA 130 EKDEKGMPVT 140 ARVVFIFGPD 150 KKLKLSILYP 160 ATTGRNFDEI 170 LRVVDSLQLT 180 ASNPVATPVD 190 WKKGESVMVL 200 PTLPEEEAKQ 210 LFPKGVFTKE 220 LPSGKKYLRY TPQP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity
Molecular Function GO:0004623 A2-type glycerophospholipase activity
Molecular Function GO:0004602 glutathione peroxidase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004601 peroxidase activity
Molecular Function GO:0051920 peroxiredoxin activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0032060 bleb assembly
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0098869 cellular oxidant detoxification
Biological Process GO:0046475 glycerophospholipid catabolic process
Biological Process GO:0042744 hydrogen peroxide catabolic process
Biological Process GO:0048026 positive regulation of mRNA splicing, via spliceosome
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0000302 response to reactive oxygen species

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.