Search Results
Overview
| Uniprot ID | O35260 |
|---|---|
| Protein Name | Nucleus accumbens-associated protein 1 |
| Gene Name | Nacc1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 206 | NGSRKMAKFSTPDLA |
Function
Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines
Protein Sequence
10
MAQTLQMEIP
20
NFGNSILECL
30
NEQRLQGLYC
40
DVSVVVKGHA
50
FKAHRAVLAA
60
SSSYFRDLFN
70
SSRSAVVELP
80
AAVQPQSFQQ
90
ILTFCYTGRL
100
SMNMGDQFLL
110
IYTAGFLQIQ
120
EIMEKGTEFF
130
LKVSSPSCDS
140
QGLHPEEAPS
150
SEPQSPVAQI
160
LGWPACSTPL
170
PLVSRVKTEQ
180
ELDSVQCTPM
190
AKRLWDSSQK
200
EAGGSGGNNG
210
SRKMAKFSTP
220
DLAPNRMPQP
230
VSVATATAAV
240
AVVAVGGCVS
250
GPSMSERTSP
260
GTSSAYTSDS
270
PSSYHNEEDE
280
EEDAGEEGTD
290
EQYRQICNMY
300
TMYSMLNVGQ
310
TVEKVEALPE
320
QVVLESHSRI
330
RVRQDLASLP
340
AELINQIGNR
350
CHPKLYDEGD
360
PSEKLELVTG
370
TNVYITRAQL
380
MNCHVSAGTR
390
HKVLLRRLLA
400
SFFDRNTLAN
410
SCGTGIRSST
420
NDPRRKPLDS
430
RVLHAVKYYC
440
QNFAPNFKES
450
EMNAIAADMC
460
TNARRVVRKS
470
WLPKTKPLHL
480
VEGDNYSSFI
490
SDTGKIEPDM
500
MSMEHSFETA
510
SHDGEAGPSA
EVLQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.