Overview
| Uniprot ID | O35264 |
|---|
| Protein Name | Platelet-activating factor acetylhydrolase IB subunit alpha2 |
|---|
| Gene Name | Pafah1b2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 155 |
PLRQKNAKVNQLLKV |
| 161 |
AKVNQLLKVSLPKLA |
Function
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF (PubMed:9660828). The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity)
Protein Sequence
10
MSQGDSNPAA
20
IPHAAEDIQG
30
DDRWMSQHNR
40
FVLDCKDKEP
50
DVLFVGDSMV
60
QLMQQYEIWR
70
ELFSPLHALN
80
FGIGGDTTRH
90
VLWRLKNGEL
100
ENIKPKVIVV
110
WVGTNNHENT
120
AEEVAGGIEA
130
IVQLINTRQP
140
QAKIIVLGLL
150
PRGEKPNPLR
160
QKNAKVNQLL
170
KVSLPKLANV
180
QLLDIDGGFV
190
HSDGAISCHD
200
MFDFLHLTGG
210
GYAKICKPLH
220
ELIMQLLEET
PEEKQTTIA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008247 |
1-alkyl-2-acetylglycerophosphocholine esterase complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0003847 |
1-alkyl-2-acetylglycerophosphocholine esterase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0047179 |
platelet-activating factor acetyltransferase activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Biological Process |
GO:0016042 |
lipid catabolic process |
| Biological Process |
GO:0016239 |
positive regulation of macroautophagy |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.