Search Results

Overview

Uniprot ID	O35274
Protein Name	Neurabin-2
Gene Name	Ppp1r9b
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
163	PAASGGDKEAVARRL
242	GAPQVNSKLVTKRSR
49	PKAAHHKKYGSNVHR

Function

Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G protein-coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration (By similarity)

Protein Sequence

10 MMKTEPRGPG 20 GPLRSASPHR 30 SAYEAGIQAL 40 KPPDAPGPDE 50 APKAAHHKKY 60 GSNVHRIKSM 70 FLQMGTTTGP 80 PGEAGGASGM 90 AEAPRASDRG 100 VRLSLPRASS 110 LNENVDHSAL 120 LKLGTSVSER 130 VSRFDSKPAP 140 SAQPAPPPHP 150 PSRLQETRKL 160 FERSVPAASG 170 GDKEAVARRL 180 LRQERASLQD 190 RKLDVVVRFN 200 GSTEALDKLD 210 ADAVSPTVSQ 220 LSAVFEKADS 230 RTGLHRAPGP 240 PRAAGAPQVN 250 SKLVTKRSRV 260 FQPPPPPPAP 270 SGDAATEKDR 280 GPGGQQPPQH 290 RVAPARPPPK 300 PREVRKIKPV 310 EVEESGESEA 320 ESAPGEVIQA 330 EVTVHAALEN 340 GSTTATTASP 350 APEEPKAEAV 360 PEEEASSSVA 370 TLERGVDNGR 380 APDMAPEEVD 390 ESKKEDFSEA 400 DLVDVSAYSG 410 LGEDSGGSAL 420 EEDDEEDEED 430 GEPPYEPESG 440 CVEIPGLSEE 450 EDPAPSRKIH 460 FSTAPIQVFS 470 TYSNEDYDRR 480 NEDVDPMAAS 490 AEYELEKRVE 500 RLELFPVELE 510 KDSEGLGISI 520 IGMGAGADMG 530 LEKLGIFVKT 540 VTEGGAAHRD 550 GRIQVNDLLV 560 EVDGTSLVGV 570 TQSFAASVLR 580 NTKGRVRFMI 590 GRERPGEQSE 600 VAQLIQQTLE 610 QERWQREMME 620 QRYAQYGEDD 630 EETGEYATDE 640 DEELSPTFPG 650 GEMAIEVFEL 660 AENEDALSPV 670 EMEPEKLVHK 680 FKELQIKHAV 690 TEAEIQQLKR 700 KLQSLEQEKG 710 RWRVEKAQLE 720 QSVEENKERM 730 EKLEGYWGEA 740 QSLCQAVDEH 750 LRETQAQYQA 760 LERKYSKAKR 770 LIKDYQQKEI 780 EFLKKETAQR 790 RVLEESELAR 800 KEEMDKLLDK 810 ISELEGNLQT LRNSNST

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0030864	cortical actin cytoskeleton
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:1990780	cytoplasmic side of dendritic spine plasma membrane
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0044327	dendritic spine head
Cellular Component	GO:0032591	dendritic spine membrane
Cellular Component	GO:0044326	dendritic spine neck
Cellular Component	GO:0098890	extrinsic component of postsynaptic membrane
Cellular Component	GO:0030175	filopodium
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0032587	ruffle membrane
Cellular Component	GO:0097444	spine apparatus
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0031749	D2 dopamine receptor binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0003676	nucleic acid binding
Molecular Function	GO:0004672	protein kinase activity
Molecular Function	GO:0008157	protein phosphatase 1 binding
Molecular Function	GO:0004864	protein phosphatase inhibitor activity
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0044325	transmembrane transporter binding
Biological Process	GO:0030042	actin filament depolymerization
Biological Process	GO:0007015	actin filament organization
Biological Process	GO:0019722	calcium-mediated signaling
Biological Process	GO:0016477	cell migration
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus
Biological Process	GO:0071392	cellular response to estradiol stimulus
Biological Process	GO:0071315	cellular response to morphine
Biological Process	GO:1901653	cellular response to peptide
Biological Process	GO:0071466	cellular response to xenobiotic stimulus
Biological Process	GO:0021987	cerebral cortex development
Biological Process	GO:0016358	dendrite development
Biological Process	GO:0003006	developmental process involved in reproduction
Biological Process	GO:0046847	filopodium assembly
Biological Process	GO:0021766	hippocampus development
Biological Process	GO:0007612	learning
Biological Process	GO:0060179	male mating behavior
Biological Process	GO:0030308	negative regulation of cell growth
Biological Process	GO:0031175	neuron projection development
Biological Process	GO:1903829	positive regulation of protein localization
Biological Process	GO:1904372	positive regulation of protein localization to actin cortical patch
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane
Biological Process	GO:1903119	protein localization to actin cytoskeleton
Biological Process	GO:1990778	protein localization to cell periphery
Biological Process	GO:2000474	regulation of opioid receptor signaling pathway
Biological Process	GO:0150052	regulation of postsynapse assembly
Biological Process	GO:0001932	regulation of protein phosphorylation
Biological Process	GO:0061458	reproductive system development
Biological Process	GO:0043200	response to amino acid
Biological Process	GO:0001975	response to amphetamine
Biological Process	GO:0032355	response to estradiol
Biological Process	GO:0035902	response to immobilization stress
Biological Process	GO:1904373	response to kainic acid
Biological Process	GO:1904386	response to L-phenylalanine derivative
Biological Process	GO:0035094	response to nicotine
Biological Process	GO:0034695	response to prostaglandin E
Biological Process	GO:0048545	response to steroid hormone
Biological Process	GO:0009410	response to xenobiotic stimulus

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.