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Overview

Uniprot IDO35303
Protein NameDynamin-1-like protein
Gene NameDnm1l
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
105 VEAEEWGKFLHTKNK
110 WGKFLHTKNKLYTDF
285 EYAFLQKKYPSLANR
581 QDNRRETKNVASAGG
616 RGMLKTSKAEELLAE
627 LLAEEKSKPIPIMPA
75 VHVSPEDKRKTTGEE
96 KNSRHLSKGVEAEEW

Function

Functions in mitochondrial and peroxisomal division (PubMed:11553726, PubMed:12499366, PubMed:12861026, PubMed:17301055, PubMed:18250306). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:11553726). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (By similarity). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (By similarity). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner. Plays an important role in mitochondrial fission during mitosis (By similarity). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (By similarity). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:18250306, PubMed:23792689). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:18250306, PubMed:23792689). Required for programmed necrosis execution (By similarity). Rhythmic control of its activity following phosphorylation at Ser-656 is essential for the circadian control of mitochondrial ATP production (By similarity)

Protein Sequence

10 MEALIPVINK 20 LQDVFNTVGA 30 DIIQLPQIVV 40 VGTQSSGKSS 50 VLESLVGRDL 60 LPRGTGVVTR 70 RPLILQLVHV 80 SPEDKRKTTG 90 EENDPATWKN 100 SRHLSKGVEA 110 EEWGKFLHTK 120 NKLYTDFDEI 130 RQEIENETER 140 ISGNNKGVSP 150 EPIHLKVFSP 160 NVVNLTLVDL 170 PGMTKVPVGD 180 QPKDIELQIR 190 ELILRFISNP 200 NSIILAVTAA 210 NTDMATSEAL 220 KISREVDPDG 230 RRTLAVITKL 240 DLMDAGTDAM 250 DVLMGRVIPV 260 KLGIIGVVNR 270 SQLDINNKKS 280 VTDSIRDEYA 290 FLQKKYPSLA 300 NRNGTKYLAR 310 TLNRLLMHHI 320 RDCLPELKTR 330 INVLAAQYQS 340 LLNSYGEPVD 350 DKSATLLQLI 360 TKFATEYCNT 370 IEGTAKYIET 380 SELCGGARIC 390 YIFHETFGRT 400 LESVDPLGGL 410 NTIDILTAIR 420 NATGPRPALF 430 VPEVSFELLV 440 KRQIKRLEEP 450 SLRCVELVHE 460 EMQRIIQHCS 470 NYSTQELLRF 480 PKLHDAIVEV 490 VTCLLRKRLP 500 VTNEMVHNLV 510 AIELAYINTK 520 HPDFADACGL 530 MNNNIEEQRR 540 NRLARELPSA 550 VSRDKSSKVP 560 SALAPASQEP 570 SPAASAEADG 580 KLIQDNRRET 590 KNVASAGGGI 600 GDGGRIGDGG 610 QEPTTGNWRG 620 MLKTSKAEEL 630 LAEEKSKPIP 640 IMPASPQKGH 650 AVNLLDVPVP 660 VARKLSAREQ 670 RDCEVIERLI 680 KSYFLIVRKN 690 IQDSVPKAVM 700 HFLVNHVKDT 710 LQSELVGQLY 720 KSSLLDDLLT 730 ESEDMAQRRK 740 EAADMLKALQ 750 GASQIIAEIR ETHLW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005903 brush border
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0099073 mitochondrion-derived vesicle
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005777 peroxisome
Cellular Component GO:0098835 presynaptic endocytic zone membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0099503 secretory vesicle
Cellular Component GO:0030672 synaptic vesicle membrane
Molecular Function GO:0051433 BH2 domain binding
Molecular Function GO:0030276 clathrin binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0030742 GTP-dependent protein binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0120283 protein serine/threonine kinase binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0071396 cellular response to lipid
Biological Process GO:0060047 heart contraction
Biological Process GO:0048312 intracellular distribution of mitochondria
Biological Process GO:0000266 mitochondrial fission
Biological Process GO:0043653 mitochondrial fragmentation involved in apoptotic process
Biological Process GO:0090149 mitochondrial membrane fission
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0160040 mitocytosis
Biological Process GO:0010637 negative regulation of mitochondrial fusion
Biological Process GO:0016559 peroxisome fission
Biological Process GO:0061003 positive regulation of dendritic spine morphogenesis
Biological Process GO:0090141 positive regulation of mitochondrial fission
Biological Process GO:0090023 positive regulation of neutrophil chemotaxis
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:1900244 positive regulation of synaptic vesicle endocytosis
Biological Process GO:2000302 positive regulation of synaptic vesicle exocytosis
Biological Process GO:0051259 protein complex oligomerization
Biological Process GO:0070585 protein localization to mitochondrion
Biological Process GO:1903578 regulation of ATP metabolic process
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0010821 regulation of mitochondrion organization
Biological Process GO:1901524 regulation of mitophagy
Biological Process GO:1900063 regulation of peroxisome organization
Biological Process GO:1904666 regulation of ubiquitin protein ligase activity
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:1905395 response to flavonoid
Biological Process GO:1990910 response to hypobaric hypoxia
Biological Process GO:0048511 rhythmic process
Biological Process GO:0048488 synaptic vesicle endocytosis
Biological Process GO:0036466 synaptic vesicle recycling via endosome

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.