Overview
| Uniprot ID | O35381 |
|---|
| Protein Name | Acidic leucine-rich nuclear phosphoprotein 32 family member A |
|---|
| Gene Name | Anp32a |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 236 |
EEGSQKRKREPDDEG |
Function
Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltransferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:29467488). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (By similarity) (PubMed:17557114, PubMed:29467488)
Protein Sequence
10
MEMDKRIYLE
20
LRNRTPSDVK
30
ELVLDNCKSI
40
EGKIEGLTDE
50
FEELEFLSTI
60
NVGLTSISNL
70
PKLNKLKKLE
80
LSENRISGDL
90
EVLAEKCPNL
100
KHLNLSGNKI
110
KDLSTIEPLK
120
KLENLKSLDL
130
FNCEVTNLNA
140
YRENVFKLLP
150
QVMYLDGYDR
160
DNKEAPDSDV
170
EGYVEDDDEE
180
DEDEEEYDEY
190
AQLVEDEEEE
200
DEEEEGEEED
210
VSGEEEEDEE
220
GYNDGEVDDE
230
EDEEEAGEEE
240
GSQKRKREPD
DEGEEDD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Molecular Function |
GO:0050839 |
cell adhesion molecule binding |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0005178 |
integrin binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0120033 |
negative regulation of plasma membrane bounded cell projection assembly |
| Biological Process |
GO:0031400 |
negative regulation of protein modification process |
| Biological Process |
GO:0006913 |
nucleocytoplasmic transport |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.