Search Results

Overview

Uniprot ID	O35412
Protein Name	Signal-induced proliferation-associated 1-like protein 1
Gene Name	Sipa1l1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
287	KPLKRRSKSETGDSS

Function

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis

Protein Sequence

10 MTSLKRSQTE 20 RPVTADRASV 30 VSTDGTPKVH 40 TDDFYMRRFR 50 SQNGSLGSSV 60 MAAVGPPRSE 70 GPHHITSTPG 80 VPKMGVRARI 90 ADWPPRKENV 100 KESSRSSQEI 110 ETSSCLESLS 120 SKGSPVSQGS 130 SVSLNSNDSA 140 MLKSIQNTLK 150 NKTGPAESMD 160 SRFLMPEAYP 170 SSPRKALRRI 180 RQRSNSDITI 190 SELDVDSFDE 200 CISPTYKSGP 210 SLHREYGSTS 220 SIDKQGTSGE 230 SFFGLLKGYK 240 DDRADRGPTP 250 TKLSDFLITG 260 GGKGSGFSLD 270 VIDGPISQRE 280 NLRLFKEREK 290 PLKRRSKSET 300 GDSSIFRKLR 310 NAKGEELGKS 320 SDLEDNRSED 330 SVRPWTCPKC 340 FAHYDVQSIL 350 FDLNEAIMNR 360 HNVIKRRNTT 370 TGASAAAVAS 380 LVSGPLSHST 390 SFSSPMGSTE 400 DFNSKGSLGM 410 DQGDDKSNEL 420 VMSCPYFRNE 430 IGGEGERKIS 440 LSKSNSGSFS 450 GCESTSFESA 460 LSSHCTNAGV 470 AVLEVPKESL 480 MLHLDRVRRY 490 TVEHVDLGAY 500 YYRKCFYQKE 510 HWNYFGADEN 520 LGPVAVSIRR 530 EKPEDMKENG 540 SPYNYRIIFR 550 TSELMTLRGS 560 VLEDAIPSTA 570 KHSTARGLPL 580 KEVLEHVIPE 590 LNVQCLRLAF 600 NTPKVTEQLM 610 KLDEQGLNYQ 620 QKVGIMYCKA 630 GQSTEEEMYN 640 TPKVTEQFMK 650 LDEQGLNYQQ 660 KVGIMYCKAG 670 QSTEEEMYNN 680 ESAGPAFEEF 690 LQLLGERVRL 700 KGFEKYRAQL 710 DTKTDSTGTH 720 SLYTTYKDYE 730 IMFHVSTMLP 740 YTPNNKQQLL 750 RKRHIGNDIV 760 TIVFQEPGAQ 770 PFSPKNIRSH 780 FQHVFVIVRA 790 HNPCTESVCY 800 SVAVTRSRDV 810 PSFGPPIPKG 820 VTFPKSNVFR 830 DFLLAKVINA 840 ENAAHKSEKF 850 RAMATRTRQE 860 YLKDLAEKNV 870 TNTPIDPSGK 880 FPFISLASKK 890 KEKSKPYPGA 900 ELSSMGAIVW 910 AVRAKDYNKA 920 MEFDCLLGIS 930 NEFIVLIEQE 940 TKSVVFNCSC 950 RDVIGWTSSD 960 SSLKIFYERG 970 ECISVESFMS 980 SEDIKEIVKR 990 LQFVSKGCES 1000 VEMTLRRNGL 1010 GQLGFHVNYE 1020 GIVADVEPYG 1030 YAWQAGLKQG 1040 SRLVEICKVA 1050 VATLSHEQMI 1060 DLLRTSVTVK 1070 VVIIPPHDDC 1080 TPRRSCSETY 1090 RMPVMEYKMN 1100 EGVSYEYKFP 1110 FRSNNKWQRN 1120 AGKGAHSPQV 1130 PLQLQSPMIS 1140 RVNAGKGDGK 1150 MPLPERAANI 1160 PRSISSDGRP 1170 LERRLSPGSD 1180 IYVTVSSMAL 1190 ARSQCRNSPS 1200 NLSSSSETGS 1210 GGGTYRQKSM 1220 PEGFGVSRRS 1230 PASIDRQNTQ 1240 SDIGGSGKST 1250 PSWQRSEDSL 1260 ADQMEPTCHL 1270 PAVSKVLPAF 1280 RESPSGRLMR 1290 QDPVVHLSPN 1300 KQGHSDSHYS 1310 SHSSSNTLSS 1320 NASSAHSDEK 1330 WYDGDRTESD 1340 LNSYNYLQGT 1350 SADSGIDTAS 1360 YGLSHGSTAS 1370 LGASTSSPRS 1380 GPGKEKVAPL 1390 WHSSSEVLSL 1400 ADRTLETEGH 1410 GMDRKTESSL 1420 SLDIHSKSQG 1430 GSSPLTRENS 1440 TFSINDATSH 1450 TSTMSSRHSA 1460 SPVVFSSARS 1470 SPKEELHPTT 1480 SSQLAPSFSS 1490 SSSSSSGPRT 1500 FYPRQGATSK 1510 YLIGWKKPEG 1520 TINSVGFMDT 1530 RKRHQSDGNE 1540 IAHTRLRAST 1550 RDLRASPKPT 1560 SKSTIEEDLK 1570 KLIDLESPTP 1580 ESQKNFKFHG 1590 LSSPQSPFPS 1600 TPTSRRALHR 1610 TLSDESIYSS 1620 QREHFFTSRA 1630 SLLDQALPND 1640 VFFSSTYPSL 1650 PKSLPLRRPS 1660 YTLGMKSLHG 1670 EFFASDSSLT 1680 DIQETRRQPI 1690 PDPGLMPLPD 1700 TASDLDWSNL 1710 VDAAKAYEVQ 1720 RASFFAASDE 1730 NHRPLSAASN 1740 SDQLEEQALV 1750 QMKSYSSSKD 1760 SSPTLASKVD 1770 QLEGMLKMLR 1780 EDLKKEKEDK 1790 AHLQAEVEHL 1800 REDNLRLQEE 1810 SQNASDKLKK 1820 FTEWVFNTID MS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098794	postsynapse
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0046875	ephrin receptor binding
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0090630	activation of GTPase activity
Biological Process	GO:0048013	ephrin receptor signaling pathway
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization
Biological Process	GO:0050770	regulation of axonogenesis
Biological Process	GO:0048814	regulation of dendrite morphogenesis
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis
Biological Process	GO:0043087	regulation of GTPase activity
Biological Process	GO:0099151	regulation of postsynaptic density assembly
Biological Process	GO:0051056	regulation of small GTPase mediated signal transduction
Biological Process	GO:0048167	regulation of synaptic plasticity

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.