Search Results
Overview
| Uniprot ID | O35458 |
|---|---|
| Protein Name | Vesicular inhibitory amino acid transporter |
| Gene Name | Slc32a1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | VATSVSNKSQAKVSG |
| 8 | MATLLRSKLTNVATS |
Function
Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals (By similarity) (PubMed:9349821). The transport is equally dependent on the chemical and electrical components of the proton gradient (PubMed:9349821). May also transport beta-alanine (PubMed:23919636). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity)
Protein Sequence
10
MATLLRSKLT
20
NVATSVSNKS
30
QAKVSGMFAR
40
MGFQAATDEE
50
AVGFAHCDDL
60
DFEHRQGLQM
70
DILKSEGEPC
80
GDEGAEPPVE
90
GDIHYQRGGA
100
PLPPSGSKDQ
110
AVGAGGEFGG
120
HDKPKITAWE
130
AGWNVTNAIQ
140
GMFVLGLPYA
150
ILHGGYLGLF
160
LIIFAAVVCC
170
YTGKILIACL
180
YEENEDGEVV
190
RVRDSYVAIA
200
NACCAPRFPT
210
LGGRVVNVAQ
220
IIELVMTCIL
230
YVVVSGNLMY
240
NSFPGLPVSQ
250
KSWSIIATAV
260
LLPCAFLKNL
270
KAVSKFSLLC
280
TLAHFVINIL
290
VIAYCLSRAR
300
DWAWEKVKFY
310
IDVKKFPISI
320
GIIVFSYTSQ
330
IFLPSLEGNM
340
QQPSEFHCMM
350
NWTHIAACVL
360
KGLFALVAYL
370
TWADETKEVI
380
TDNLPGSIRA
390
VVNIFLVAKA
400
LLSYPLPFFA
410
AVEVLEKSLF
420
QEGSRAFFPA
430
CYGGDGRLKS
440
WGLTLRCALV
450
VFTLLMAIYV
460
PHFALLMGLT
470
GSLTGAGLCF
480
LLPSLFHLRL
490
LWRKLLWHQV
500
FFDVAIFVIG
510
GICSVSGFVH
520
SLEGLIEAYR
TNAED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0051286 | cell tip |
| Cellular Component | GO:0044316 | cone cell pedicle |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0044292 | dendrite terminus |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0060077 | inhibitory synapse |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Molecular Function | GO:0015185 | gamma-aminobutyric acid transmembrane transporter activity |
| Molecular Function | GO:0140800 | gamma-aminobutyric acid:proton antiporter activity |
| Molecular Function | GO:0015187 | glycine transmembrane transporter activity |
| Molecular Function | GO:0140799 | glycine:proton antiporter activity |
| Biological Process | GO:0001762 | beta-alanine transport |
| Biological Process | GO:0051939 | gamma-aminobutyric acid import |
| Biological Process | GO:0015812 | gamma-aminobutyric acid transport |
| Biological Process | GO:0015816 | glycine transport |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0098700 | neurotransmitter loading into synaptic vesicle |
| Biological Process | GO:0006836 | neurotransmitter transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.