Overview
| Uniprot ID | O35509 |
|---|
| Protein Name | Ras-related protein Rab-11B |
|---|
| Gene Name | Rab11b |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 179 |
IYRIVSQKQIADRAA |
| 24 |
IGDSGVGKSNLLSRF |
| 61 |
QVDGKTIKAQIWDTA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth. Also interacts with RABL3 to promote ciliary vesicle formation (By similarity)
Protein Sequence
10
MGTRDDEYDY
20
LFKVVLIGDS
30
GVGKSNLLSR
40
FTRNEFNLES
50
KSTIGVEFAT
60
RSIQVDGKTI
70
KAQIWDTAGQ
80
ERYRAITSAY
90
YRGAVGALLV
100
YDIAKHLTYE
110
NVERWLKELR
120
DHADSNIVIM
130
LVGNKSDLRH
140
LRAVPTDEAR
150
AFAEKNNLSF
160
IETSALDSTN
170
VEEAFKNILT
180
EIYRIVSQKQ
190
IADRAAHDES
200
PGNNVVDISV
210
PPTTDGQKPN
KLQCCQNL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0045335 |
phagocytic vesicle |
| Cellular Component |
GO:0030670 |
phagocytic vesicle membrane |
| Cellular Component |
GO:0055037 |
recycling endosome |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0031489 |
myosin V binding |
| Biological Process |
GO:0150093 |
amyloid-beta clearance by transcytosis |
| Biological Process |
GO:0071468 |
cellular response to acidic pH |
| Biological Process |
GO:0045054 |
constitutive secretory pathway |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0090150 |
establishment of protein localization to membrane |
| Biological Process |
GO:0035773 |
insulin secretion involved in cellular response to glucose stimulus |
| Biological Process |
GO:0032402 |
melanosome transport |
| Biological Process |
GO:0001881 |
receptor recycling |
| Biological Process |
GO:0045055 |
regulated exocytosis |
| Biological Process |
GO:1902017 |
regulation of cilium assembly |
| Biological Process |
GO:2001135 |
regulation of endocytic recycling |
| Biological Process |
GO:0044070 |
regulation of monoatomic anion transport |
| Biological Process |
GO:0099161 |
regulation of presynaptic dense core granule exocytosis |
| Biological Process |
GO:2000008 |
regulation of protein localization to cell surface |
| Biological Process |
GO:0033572 |
transferrin transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.