Search Results
Overview
| Uniprot ID | O35814 |
|---|---|
| Protein Name | Stress-induced-phosphoprotein 1 |
| Gene Name | Stip1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 162 | LIEQLQNKPSDLGTK |
| 210 | PPPKKEAKPEPMEED |
| 229 | KKQALKEKELGNDAY |
| 246 | KDFDKALKHYDKAKE |
| 284 | KCRELCEKAIEVGRE |
| 317 | YFKEERYKDAIHFYN |
| 325 | DAIHFYNKSLAEHRT |
| 364 | PDLALEEKNKGNECF |
| 373 | KGNECFQKGDYPQAM |
| 388 | KHYTEAIKRNPRDAK |
| 442 | AAALEAMKDYTKAMD |
| 462 | LDLDSSCKEAADGYQ |
| 78 | WGKGYSRKAAALEFL |
Function
Acts as a co-chaperone for HSP90AA1 (By similarity). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (PubMed:9528774)
Protein Sequence
10
MEQVNELKEK
20
GNKALSAGNI
30
DDALQCYSEA
40
IKLDPQNHVL
50
YSNRSAAYAK
60
KGDYQKAYED
70
GCKTVDLKPD
80
WGKGYSRKAA
90
ALEFLNRFEE
100
AKRTYEEGLK
110
HEANNLQLKE
120
GLQNMEARLA
130
ERKFMNPFNL
140
PNLYQKLEND
150
PRTRTLLSDP
160
TYRELIEQLQ
170
NKPSDLGTKL
180
QDPRVMTTLS
190
VLLGVDLGSM
200
DEEEEAATPP
210
PPPPPKKEAK
220
PEPMEEDLPE
230
NKKQALKEKE
240
LGNDAYKKKD
250
FDKALKHYDK
260
AKELDPTNMT
270
YITNQAAVHF
280
EKGDYNKCRE
290
LCEKAIEVGR
300
ENREDYRQIA
310
KAYARIGNSY
320
FKEERYKDAI
330
HFYNKSLAEH
340
RTPDVLKKCQ
350
QAEKILKEQE
360
RLAYINPDLA
370
LEEKNKGNEC
380
FQKGDYPQAM
390
KHYTEAIKRN
400
PRDAKLYSNR
410
AACYTKLLEF
420
QLALKDCEEC
430
IQLEPTFIKG
440
YTRKAAALEA
450
MKDYTKAMDV
460
YQKALDLDSS
470
CKEAADGYQR
480
CMMAQYNRHD
490
SPEDVKRRAM
500
ADPEVQQIMS
510
DPAMRLILEQ
520
MQKDPQALSE
530
HLKNPVIAQK
540
IQKLMDVGLI
AIR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0120293 | dynein axonemal particle |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0101031 | protein folding chaperone complex |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0098761 | cellular response to interleukin-7 |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.