Search Results

Overview

Uniprot ID	O35821
Protein Name	Myb-binding protein 1A
Gene Name	Mybbp1a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1175	ISTKRKKKGFLPETK
1188	TKKRKKLKSEGTTSE
1262	SPSTPPAKTPKVQKK
9	AEMKSPTKAEPASPA

Function

May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (By similarity)

Protein Sequence

10 MAEMKSPTKA 20 EPASPAEAPQ 30 GDRRSLLEHS 40 REFLDFFWDI 50 AKPDQETRLR 60 ATEKLLEYLR 70 TRPSDSEMKY 80 ALKRLITGLG 90 VGREAARPCY 100 SLALAQLLQS 110 FEDIQLCDIL 120 GQIQEKYNLQ 130 AMNKAMMRPT 140 LFANLFGVLA 150 LFQSGRLVKD 160 KEALMKCVRL 170 LKILSHHYNH 180 LQGQPVKALV 190 DILSEVPESM 200 FQEILPKVLK 210 GDMKVILSSP 220 KYLELFLLAR 230 QRVPAELESL 240 VGSVDLFSED 250 NIPSLVNILK 260 VAANSVKKEQ 270 KLPDVALNLL 280 RLALQENKFE 290 RFWKEVLEEG 300 LLKKPSYTSS 310 YMCFRLLGAS 320 LPLLSDEQLQ 330 LVMRGDLIRH 340 FGEHMVVSKS 350 QNPLRFIPEI 360 SAYVGTFLEG 370 CQDDPKRQFT 380 VMVAFTAITN 390 QGLPVMPTFW 400 RVTRFLNTEA 410 LQNYVTWLRD 420 MFLQPDLDSL 430 VDFSTANQKR 440 VQVASLNVPE 450 RTVFRLRKWI 460 IHRLVSLVDH 470 LHLEKDEAVV 480 EQIARFCLFH 490 AFFKTKKATP 500 QIPETKQHFS 510 FPLEDGNRGV 520 IVSAFFSLLQ 530 TLSVKFRQTP 540 DLAENGKPWT 550 YRLVQLADML 560 LKHNRNVANV 570 TPLTAQQRQA 580 WDQMMSTLKE 590 LEAQSSETRA 600 IAFQHLLLLV 610 GLHLFKSPAE 620 SCDVLGDIQT 630 CIKKSMEQNL 640 RRSRSRAKAS 650 QEPVWVEVMV 660 EILLSLLAQP 670 SNLMRQVVRS 680 VFGHVCSHLT 690 PRGLQLILAV 700 LNPETNEDEE 710 DNVVVTDTDE 720 KQLKHGEDAD 730 SDSEDSKNSE 740 SDVDSEDGEE 750 SEEEDRDKDV 760 DPGFRQQLME 770 VLQAGNALGG 780 EEEEEEELGD 790 EAMMALDQNL 800 ASLFAEQKMR 810 IQARHEEKNK 820 LQKEKQLRRD 830 FQIRALDLIE 840 VLVTKQPEHP 850 LILELLEPLL 860 NIIQRSMRSR 870 GSTKQEQDLL 880 HKTARIFMHH 890 LCRARHYCHE 900 VEPGAEALHA 910 QVERLVQQAG 920 NQADASVALY 930 YFNASLYLLR 940 VLKGNTTKRY 950 QDGQKLEGAD 960 IKSEPKDSEV 970 QTTSCLDLDF 980 VTRVYSASLE 990 SLLTKRNSPL 1000 TIPMFLDLFS 1010 RYPVICKNLL 1020 PIVVQHVAGS 1030 SRPRHQAQAC 1040 LLLQKALSAR 1050 ELRVCFEDPE 1060 WEQLISQVLG 1070 KTTQTLQTLG 1080 EAQSKGEHQR 1090 ELSILELLNT 1100 VFRIVNHEKL 1110 SVDLTAFLGM 1120 LQGKQQKLQQ 1130 NLQQGNHSSG 1140 SSRLYDLYWQ 1150 AMNLLGVQRP 1160 KSEKKNVKDI 1170 PSDSQSPIST 1180 KRKKKGFLPE 1190 TKKRKKLKSE 1200 GTTSEKKAAS 1210 QQDAVTEGAM 1220 PAATGKDQPP 1230 STGKKRRKRV 1240 KANTPSQVNG 1250 VTVAKSPAPN 1260 NPTLSPSTPP 1270 AKTPKVQKKK 1280 EKLSQVNGST 1290 PVSPVEPESK 1300 KHQKALSTKE 1310 VKRRSSQSAL 1320 PKKRARLSLV 1330 SRSPSLLQSG 1340 IRKRRVARRR VQTP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0110016	B-WICH complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0042564	NLS-dependent protein nuclear import complex
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0070888	E-box binding
Molecular Function	GO:0043565	sequence-specific DNA binding
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0042149	cellular response to glucose starvation
Biological Process	GO:0032922	circadian regulation of gene expression
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:2000210	positive regulation of anoikis
Biological Process	GO:0045945	positive regulation of transcription by RNA polymerase III
Biological Process	GO:1903450	regulation of G1 to G0 transition
Biological Process	GO:0022904	respiratory electron transport chain
Biological Process	GO:0042254	ribosome biogenesis

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.