Search Results

Overview

Uniprot IDO35855
Protein NameBranched-chain-amino-acid aminotransferase, mitochondrial
Gene NameBcat2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
43 DLQIQMTKEPQKKPA

Function

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (PubMed:14755340, PubMed:17767905). Branched chain amino acid catabolism plays a role in adipocyte differentiation by providing lipogenic acetyl-CoA pools in differentiated adipocytes (PubMed:17767905, PubMed:35075301). Mechanistically, acetyl-CoA derived from branched chain amino acid catabolism is used by EP300/p300 to acetylate and inhibit PRDM16, thereby preventing adipose tissue browning (PubMed:35075301). May also function as a transporter of branched chain alpha-keto acids (By similarity)

Protein Sequence

10 MAAATLGQVW 20 ARKLLPVPWL 30 LCGSKRCVSS 40 IFKAADLQIQ 50 MTKEPQKKPA 60 PSQALLFGKT 70 FTDHMLMVEW 80 NNKAGWGPPR 90 IQPFQNLTLH 100 PACSGLHYSL 110 QLFEGLKAYK 120 GGDQQVRLFR 130 PWLNMDRMLR 140 SARRLCLPDF 150 DKQELLECIR 160 QLIEVDKDWV 170 PDGNGTSLYV 180 RPVLIGNEPS 190 LGVGMVTQAL 200 LYVILCPVGS 210 YFPGDSMTPV 220 SLLADPSFVR 230 AWIGGVGDCK 240 LGGNYGPTVA 250 VQREAQKRGC 260 EQVLWLYGPD 270 HQLTEVGTMN 280 IFVYWTHEDG 290 VLELVTPPLN 300 GVILPGVVRQ 310 SLLDLARTWG 320 EFRVAERKVT 330 MKELKRALEE 340 GRVREVFGSG 350 TACQVCPVHQ 360 ILYEGKQLHI 370 PTMENGPELI 380 LRFQKELKAI 390 QYGASAHDWM FRV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0004084 branched-chain-amino-acid transaminase activity
Molecular Function GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Molecular Function GO:0052654 L-leucine-2-oxoglutarate transaminase activity
Molecular Function GO:0052655 L-valine-2-oxoglutarate transaminase activity
Biological Process GO:0009083 branched-chain amino acid catabolic process
Biological Process GO:0009081 branched-chain amino acid metabolic process
Biological Process GO:0050873 brown fat cell differentiation
Biological Process GO:1990830 cellular response to leukemia inhibitory factor
Biological Process GO:0097009 energy homeostasis
Biological Process GO:0006549 isoleucine metabolic process
Biological Process GO:0006550 L-isoleucine catabolic process
Biological Process GO:0009098 L-leucine biosynthetic process
Biological Process GO:0006551 L-leucine metabolic process
Biological Process GO:0009099 L-valine biosynthetic process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0010817 regulation of hormone levels
Biological Process GO:0006573 valine metabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.