Search Results
Overview
| Uniprot ID | O35857 |
|---|---|
| Protein Name | Mitochondrial import inner membrane translocase subunit TIM44 |
| Gene Name | Timm44 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | TSEAIKKKLGELTGT |
| 405 | VMVIKNSKGEVYDGD |
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (PubMed:31618756). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity)
Protein Sequence
10
MAAAALRGGW
20
CRCPRRCLGS
30
GIQFLSSHNL
40
PHGSSYQISR
50
PGRELTLTKS
60
YSSGSRKGFL
70
SGLLDNIKQE
80
LAKNKEMKES
90
IKKFRDEAKK
100
LEESDALQEA
110
RRKYKSIESE
120
TVRTSEAIKK
130
KLGELTGTVK
140
ESLDEVSKSD
150
LGRKIKEGVE
160
EAARTAKQSA
170
ESVSKSGEKL
180
GKTAAFKAIS
190
QGVESVKKEL
200
DESVLGQTGP
210
YRRPERLRKR
220
TEFAGAKFKE
230
SKVFEANEEA
240
LGVVLHKDSK
250
WYQQWKDFKD
260
NNVVFNRFFE
270
MKMKYDESDN
280
VLIRASRALT
290
DKVTDLLGGL
300
FSKTEMSEVL
310
TEILRVDPTF
320
DKDHFLHQCE
330
TDIIPNILEA
340
MISGELDILK
350
DWCYEATYSQ
360
LAHPIQQAKA
370
LGFQFHSRIL
380
DISNVDLAMG
390
KMMEQGPVLI
400
VTFQAQVVMV
410
IKNSKGEVYD
420
GDPDKVQRML
430
YVWALCRDQE
440
ELNPYAAWRL
450
LDISASSTEQ
IL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0030150 | protein import into mitochondrial matrix |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.