Overview
| Uniprot ID | O35876 |
|---|
| Protein Name | Survival motor neuron protein |
|---|
| Gene Name | Smn1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 53 |
ASFKHALKNGDMCET |
Function
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)
Protein Sequence
10
MAMGSGGGAG
20
SEQEDTVLFR
30
RGTGQSDDSD
40
IWDDTALIKA
50
YDKAVASFKH
60
ALKNGDMCET
70
SDKPKGTARR
80
KPAKKNKNQK
90
KNATAPLKQW
100
KAGDKCSAVW
110
SEDGCVYPAT
120
ITSVDLKRET
130
CVVVYTGYGN
140
KEEQNLSDLL
150
SPTCEVANNT
160
EQNTQENESQ
170
VSTDDSEHSS
180
RSLRSKAHSK
190
SKAAPWTSFL
200
PPPPPVPGAG
210
LGPGKPGLRF
220
SGPPPPPPPP
230
PPFLPCWMPP
240
FPSGPPIIPP
250
PPPISPDCLD
260
DTDALGSMLI
270
SWYMSGYHTG
280
YYMGFRQNKK
EGKKCSHTN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015030 |
Cajal body |
| Cellular Component |
GO:0030137 |
COPI-coated vesicle |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0036464 |
cytoplasmic ribonucleoprotein granule |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0097504 |
Gemini of Cajal bodies |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0030426 |
growth cone |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0043204 |
perikaryon |
| Cellular Component |
GO:0032797 |
SMN complex |
| Cellular Component |
GO:0034719 |
SMN-Sm protein complex |
| Cellular Component |
GO:0030018 |
Z disc |
| Molecular Function |
GO:0017134 |
fibroblast growth factor binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0007409 |
axonogenesis |
| Biological Process |
GO:0007268 |
chemical synaptic transmission |
| Biological Process |
GO:0006353 |
DNA-templated transcription termination |
| Biological Process |
GO:0007019 |
microtubule depolymerization |
| Biological Process |
GO:0033120 |
positive regulation of RNA splicing |
| Biological Process |
GO:0010975 |
regulation of neuron projection development |
| Biological Process |
GO:0000245 |
spliceosomal complex assembly |
| Biological Process |
GO:0000387 |
spliceosomal snRNP assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.