Search Results
Overview
| Uniprot ID | O35889 |
|---|---|
| Protein Name | Afadin |
| Gene Name | Afdn |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1812 | QGQDVSDKVKASRKL |
| 1818 | DKVKASRKLTELENE |
Function
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (PubMed:9334353). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:9334353). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (By similarity)
Protein Sequence
10
MSAGGRDEER
20
RKLADIIHHW
30
NANRLDLFEI
40
SQPTEDLEFH
50
GVMRFYFQDK
60
AAGNFATKCI
70
RVSSTATTQD
80
VIETLAEKFR
90
PDMRMLSSPK
100
YSLYEVHVSG
110
ERRLDIDEKP
120
LVVQLNWNKD
130
DREGRFVLKN
140
ENDAIPAKKA
150
QSNGPEKQEK
160
EGVIQNFKRT
170
LSKKEKKEKK
180
KREKEALRQA
190
SDKEERPSQG
200
DDSENSRLAA
210
EVYKDMPETS
220
FTRTISNPEV
230
VMKRRRQQKL
240
EKRMQEFRSS
250
DGRPDSGGTL
260
RIYADSLKPN
270
IPYKTILLST
280
TDPADFAVAE
290
SLEKYGLEKE
300
NPKDYCIARV
310
MLPPGAQHSD
320
ERGAKEIILD
330
DDECPLQIFR
340
EWPSDKGILV
350
FQLKRRPPDY
360
IPKKMKKHVE
370
GKPLKGKDRA
380
DGSGYGSALP
390
PEKLPYLVEL
400
SPGRRNHFAY
410
YSYHTYEDGS
420
DSRDKPKLYR
430
LQLSVTEVGT
440
EKFDDNSIQL
450
FGPGIQPHHC
460
DLTNMDGVVT
470
VTPRSMDAET
480
YVDGQRISET
490
TMLQSGMRLQ
500
FGTSHVFKFV
510
DPIQDHVLSK
520
RSVDGGLMVK
530
GPRHKPGAVQ
540
ETTFELGGDI
550
HSGTALPASR
560
STTRLDSDRV
570
SSASSTAERG
580
MVKPMIRLDQ
590
EQDYRRRESR
600
TQDAAGPELM
610
LPASIEFRES
620
SEDSFLSAII
630
NYTNSSTVHF
640
KLSPTYVLYM
650
ACRYVLSSQH
660
RPDISPTERT
670
HKAIAVVNKM
680
VSMMEGVIQE
690
VDQVDQKQKN
700
IAGALAFWMA
710
NASELLNFIK
720
QDRDLSRITL
730
DAQDVLAHLV
740
QMAFKYLVHC
750
LQSELNNYMP
760
AFLDDPEENS
770
LQRPKIDDVL
780
HTLTGAMSLL
790
RRCRVNAALT
800
IQLFSQLFHF
810
INMWLFNRLV
820
TDPDSGLCSH
830
YWGAIIRQQL
840
GHIEAWAEKQ
850
GLELAADCHL
860
SRIVQATTLL
870
TMDKYVPDDI
880
PNINSTCFKL
890
NSLQLQALLQ
900
NYHCAPDEPF
910
IPTDLIENVV
920
AVAENTADEL
930
ARSDGRDVQL
940
EEDPDLQLPF
950
LLPEDGYSCD
960
VVRNIPNGLQ
970
EFLDPLCQRG
980
FCRLVPHTRS
990
PGTWTIYFEG
1000
ADYESHLMRE
1010
NTELTQPLRK
1020
EPEVITVTLK
1030
KQNGMGLSIV
1040
AAKGAGQDKL
1050
GIYVKSVVKG
1060
GAADVDGRLA
1070
AGDQLLSVDG
1080
RSLVGLSQER
1090
AAELMTRTSS
1100
VVTLEVAKQG
1110
AIYHGLATLL
1120
NQPSPMMQRI
1130
SDRRGSGKPR
1140
PKSEGFELYN
1150
NSAQNGSPES
1160
PQMPWTEYSE
1170
PKKLPGDDRL
1180
MKNRADHRSS
1190
PNVANQPPSP
1200
GGKSPYTSGT
1210
AAKITSVSTG
1220
NLCTEEQTPP
1230
PRPEAYPIPT
1240
QTYTREYFTF
1250
PASKSQDRMA
1260
PVQNQWPNYE
1270
EKPHMHTESD
1280
HASIAIQRVT
1290
RSQEELREEK
1300
VYQLERHRVE
1310
SGMDRKCDSD
1320
MWINQSSSVE
1330
SSTSSQEHLN
1340
HSSKSVTPAS
1350
TLTKSGPGRW
1360
KTPAAVLPTP
1370
VAVSQPIRTD
1380
LPPPPPPPPA
1390
HYTSDFDGIS
1400
MDLPLPPPPA
1410
NQAAPQSAQV
1420
AAAERKKREE
1430
HQRWYEKEKA
1440
RLEEERERKR
1450
REQERKLGQM
1460
RTQSLNPASF
1470
SPLATQAKPE
1480
KPSTLQRPQE
1490
TVIRELQPQQ
1500
QPRTIERRDL
1510
QYITISKEEL
1520
SSGDSLSPDP
1530
WKRDAREKLE
1540
KQQQMHIVDM
1550
LSKEIHELQN
1560
KGDRTAEESD
1570
RLRKLMLEWQ
1580
FQKRLQESKQ
1590
KDEDDDEEED
1600
DDVDTMLIMQ
1610
RLEAERRARL
1620
QDEERRRQQQ
1630
LEEMRKREVE
1640
DRVRQEEDGR
1650
HQEEERVKRD
1660
AEEKRRQEEG
1670
YYSRLEAERR
1680
RQHEEAARRL
1690
LEPEEPGLSR
1700
PPLPQDYEPP
1710
SQSSAPSAPP
1720
PPPQRNASYL
1730
KTQVLSPDSL
1740
FTAKFVAYDD
1750
DDEEENYVPA
1760
GPNSYSGSAG
1770
TTAGTYDAPR
1780
DTREKLSRSQ
1790
DADLPGSSGA
1800
PENLTFRERQ
1810
RLFSQGQDVS
1820
DKVKASRKLT
ELENELNTK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0043296 | apical junction complex |
| Cellular Component | GO:0045177 | apical part of cell |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0044291 | cell-cell contact zone |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098686 | hippocampal mossy fiber to CA3 synapse |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0046930 | pore complex |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0048787 | presynaptic active zone membrane |
| Cellular Component | GO:0036477 | somatodendritic compartment |
| Cellular Component | GO:0070160 | tight junction |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0050839 | cell adhesion molecule binding |
| Molecular Function | GO:0030274 | LIM domain binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0034334 | adherens junction maintenance |
| Biological Process | GO:0070830 | bicellular tight junction assembly |
| Biological Process | GO:0048854 | brain morphogenesis |
| Biological Process | GO:0044331 | cell-cell adhesion mediated by cadherin |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0140059 | dendrite arborization |
| Biological Process | GO:0090557 | establishment of endothelial intestinal barrier |
| Biological Process | GO:0061951 | establishment of protein localization to plasma membrane |
| Biological Process | GO:0048872 | homeostasis of number of cells |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0060563 | neuroepithelial cell differentiation |
| Biological Process | GO:0046931 | pore complex assembly |
| Biological Process | GO:0022409 | positive regulation of cell-cell adhesion |
| Biological Process | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin |
| Biological Process | GO:1903861 | positive regulation of dendrite extension |
| Biological Process | GO:0050775 | positive regulation of dendrite morphogenesis |
| Biological Process | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0061885 | positive regulation of mini excitatory postsynaptic potential |
| Biological Process | GO:0099084 | postsynaptic specialization organization |
| Biological Process | GO:1902414 | protein localization to cell junction |
| Biological Process | GO:0060019 | radial glial cell differentiation |
| Biological Process | GO:0070445 | regulation of oligodendrocyte progenitor proliferation |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0021537 | telencephalon development |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.