Search Results
Overview
| Uniprot ID | O35910 |
|---|---|
| Protein Name | Monocarboxylate transporter 4 |
| Gene Name | Slc16a3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 454 | REVEHFLKAEPEKNG |
Function
Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (By similarity) (PubMed:10926847, PubMed:9632638). Plays a predominant role in the L-lactate efflux from highly glycolytic cells (PubMed:10926847, PubMed:9632638)
Protein Sequence
10
MGGAVVDEGP
20
TGIKAPDGGW
30
GWAVLFGCFI
40
ITGFSYAFPK
50
AVSVFFKELM
60
HEFGIGYSDT
70
AWISSILLAM
80
LYGTGPLCSM
90
CVNRFGCRPV
100
MLVGGLFASL
110
GMVAASFCRS
120
IIQIYLTTGV
130
ITGLGLALNF
140
QPSLIMLNRY
150
FNKRRPMANG
160
LAAAGSPVFL
170
CALSPLGQLL
180
QDHYGWRGGF
190
LILGGLLLNC
200
CVCAALMRPL
210
VAPQASGGAE
220
PHGPQRPSPR
230
LLDLSVFRDR
240
GFLIYAVAAS
250
IMVLGLFVPP
260
VFVVSYAKDM
270
GVPDTKAAFL
280
LTILGFIDIF
290
ARPTAGFITG
300
LKKVRPYSVY
310
LFSFAMFFNG
320
FTDLTGSTAS
330
DYGGLVVFCI
340
FFGISYGMVG
350
ALQFEVLMAI
360
VGTQKFSSAI
370
GLVLLLEAVA
380
VLIGPPSGGK
390
LLDATKVYKY
400
VFILAGAEVL
410
TSSLVLLLGN
420
FFCIGKRKRP
430
EVTKPEEVAS
440
EEEKLHKPPV
450
DVRVDSREVE
460
HFLKAEPEKN
470
GEVVHTPETS
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0015129 | lactate transmembrane transporter activity |
| Molecular Function | GO:0015650 | lactate:proton symporter activity |
| Molecular Function | GO:0050833 | pyruvate transmembrane transporter activity |
| Biological Process | GO:0035873 | lactate transmembrane transport |
| Biological Process | GO:0035879 | plasma membrane lactate transport |
| Biological Process | GO:0042867 | pyruvate catabolic process |
| Biological Process | GO:1901475 | pyruvate transmembrane transport |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.