Search Results
Overview
| Uniprot ID | O35952 |
|---|---|
| Protein Name | Hydroxyacylglutathione hydrolase, mitochondrial |
| Gene Name | Hagh |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | GGNEKLVKLEPGLKV |
| 305 | RREKDQFKVPRD*** |
Function
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid
Protein Sequence
10
MVLGRGSLCL
20
RSLSVLGAAC
30
ARRGLGQALL
40
GLSLCHTDFR
50
KNLTVQQDMM
60
KIELLPALTD
70
NYMYLIIDED
80
TQEAAVVDPV
90
QPQKVIETVK
100
KHRVKLTTVL
110
TTHHHWDHAG
120
GNEKLVKLEP
130
GLKVYGGDDR
140
IGALTHKVTH
150
LSTLEVGSLS
160
VKCLSTPCHT
170
SGHICYFVSK
180
PGSSEPSAVF
190
TGDTLFVAGC
200
GKFYEGTADE
210
MYKALLEVLG
220
RLPPDTKVIC
230
GHEYTVNNLK
240
FARHVEPGNT
250
AVQEKLAWAK
260
EKNAIGEPTV
270
PSTLAEEFTY
280
NPFMRVKEKT
290
VQQHAGETDP
300
VTTMRAIRRE
KDQFKVPRD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004416 | hydroxyacylglutathione hydrolase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006750 | glutathione biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.