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Overview

Uniprot IDO35964
Protein NameEndophilin-A2
Gene NameSh3gl1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
12 GLKKQFYKASQLVSE
177 YKKKRQGKIPDEELR
189 ELRQALEKFEESKEV
20 ASQLVSEKVGGAEGT
301 KPTRTPSKSMPPLDQ
67 PNPASRAKLTMLNTV
76 TMLNTVSKIRGQVKN

Function

Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles (By similarity). May recruit other proteins to membranes with high curvature (By similarity)

Protein Sequence

10 MSVAGLKKQF 20 YKASQLVSEK 30 VGGAEGTKLD 40 DDFREMEKKV 50 DITSKAVAEV 60 LVRTIEYLQP 70 NPASRAKLTM 80 LNTVSKIRGQ 90 VKNPGYPQSE 100 GLLGECMVRH 110 GKELGGESNF 120 GDALLDAGES 130 MKRLAEVKDS 140 LDIEVKQNFI 150 DPLQNLCDKD 160 LKEIQHHLKK 170 LEGRRLDFDY 180 KKKRQGKIPD 190 EELRQALEKF 200 EESKEVAETS 210 MHNLLETDIE 220 QVSQLSALVD 230 AQLDYHRQAV 240 QILEELADKL 250 KRRVREASSR 260 PRREFKPRPQ 270 EPFELGELEQ 280 PNGGFPCASA 290 PKITASSSFR 300 SGDKPTRTPS 310 KSMPPLDQPS 320 CKALYDFEPE 330 NDGELGFREG 340 DLITLTNQID 350 ENWYEGMLHG 360 QSGFFPLSYV QVLVPLPQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098686 hippocampal mossy fiber to CA3 synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0002102 podosome
Cellular Component GO:0099092 postsynaptic density, intracellular component
Cellular Component GO:0098793 presynapse
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0045202 synapse
Molecular Function GO:0031697 beta-1 adrenergic receptor binding
Molecular Function GO:0051020 GTPase binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0019902 phosphatase binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0017124 SH3 domain binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0061024 membrane organization
Biological Process GO:0098815 modulation of excitatory postsynaptic potential
Biological Process GO:1900244 positive regulation of synaptic vesicle endocytosis
Biological Process GO:1900242 regulation of synaptic vesicle endocytosis

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.