Overview
| Uniprot ID | O35987 |
|---|
| Protein Name | NSFL1 cofactor p47 |
|---|
| Gene Name | Nsfl1c |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 127 |
DDLFKGAKEHGAVAV |
| 251 |
VKPKGAFKAFTGEGQ |
Function
Reduces the ATPase activity of VCP (PubMed:9214505, PubMed:9824302). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (PubMed:12411482). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (PubMed:10930451). Inhibits the activity of CTSL (in vitro) (By similarity). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (By similarity). Also, regulates spindle orientation during mitosis (By similarity)
Protein Sequence
10
MAEERQDALR
20
EFVAVTGAEE
30
DRARFFLESA
40
GWDLQIALAS
50
FYEDGGDEDI
60
VTISQATPSS
70
VSRGTAPSDN
80
RVTSFRDLIH
90
DQDEEEEEEE
100
GQRFYAGGSE
110
RSGQQIVGPP
120
RKKSPNELVD
130
DLFKGAKEHG
140
AVAVERVTKS
150
PGETSKPRPF
160
AGGGYRLGAA
170
PEEESAYVAG
180
ERRRHSGQDV
190
HVVLKLWKTG
200
FSLDNGDLRS
210
YQDPSNAQFL
220
ESIRRGEVPA
230
ELRRLAHGGQ
240
VNLDMEDHRD
250
EDFVKPKGAF
260
KAFTGEGQKL
270
GSTAPQVLNT
280
SSPAQQAENE
290
AKASSSILIN
300
EAEPTTNIQI
310
RLADGGRLVQ
320
KFNHSHRISD
330
IRLFIVDARP
340
AMAATSFVLM
350
TTFPNKELAD
360
ENQTLKEANL
370
LNAVIVQRLT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005795 |
Golgi stack |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0031616 |
spindle pole centrosome |
| Cellular Component |
GO:1990730 |
VCP-NSFL1C complex |
| Molecular Function |
GO:0051117 |
ATPase binding |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0043130 |
ubiquitin binding |
| Biological Process |
GO:0000045 |
autophagosome assembly |
| Biological Process |
GO:0000132 |
establishment of mitotic spindle orientation |
| Biological Process |
GO:0007030 |
Golgi organization |
| Biological Process |
GO:0061025 |
membrane fusion |
| Biological Process |
GO:1904780 |
negative regulation of protein localization to centrosome |
| Biological Process |
GO:0031468 |
nuclear membrane reassembly |
| Biological Process |
GO:0046604 |
positive regulation of mitotic centrosome separation |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.