Search Results

Overview

Uniprot ID	O43148
Protein Name	mRNA cap guanine-N(7) methyltransferase
Gene Name	RNMT
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
114	RETEDVPKDKSSTGD
116	TEDVPKDKSSTGDGT
128	DGTQNKRKIALEDVP
137	ALEDVPEKQKNLEEG
83	DTPSKKRKLDPEIVP

Function

Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884)

Protein Sequence

10 MANSAKAEEY 20 EKMSLEQAKA 30 SVNSETESSF 40 NINENTTASG 50 TGLSEKTSVC 60 RQVDIARKRK 70 EFEDDLVKES 80 SSCGKDTPSK 90 KRKLDPEIVP 100 EEKDCGDAEG 110 NSKKRKRETE 120 DVPKDKSSTG 130 DGTQNKRKIA 140 LEDVPEKQKN 150 LEEGHSSTVA 160 AHYNELQEVG 170 LEKRSQSRIF 180 YLRNFNNWMK 190 SVLIGEFLEK 200 VRQKKKRDIT 210 VLDLGCGKGG 220 DLLKWKKGRI 230 NKLVCTDIAD 240 VSVKQCQQRY 250 EDMKNRRDSE 260 YIFSAEFITA 270 DSSKELLIDK 280 FRDPQMCFDI 290 CSCQFVCHYS 300 FESYEQADMM 310 LRNACERLSP 320 GGYFIGTTPN 330 SFELIRRLEA 340 SETESFGNEI 350 YTVKFQKKGD 360 YPLFGCKYDF 370 NLEGVVDVPE 380 FLVYFPLLNE 390 MAKKYNMKLV 400 YKKTFLEFYE 410 EKIKNNENKM 420 LLKRMQALEP 430 YPANESSKLV 440 SEKVDDYEHA 450 AKYMKNSQVR 460 LPLGTLSKSE 470 WEATSIYLVF AFEKQQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0001650	fibrillar center
Cellular Component	GO:0160130	mRNA cap methyltransferase RNMT:RAMAC complex
Cellular Component	GO:0031533	mRNA capping enzyme complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0043235	receptor complex
Molecular Function	GO:0004482	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006370	7-methylguanosine mRNA capping

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.