Search Results

Overview

Uniprot IDO43157
Protein NamePlexin-B1
Gene NamePLXNB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2131 IAAAVENKVTDL***

Function

Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496)

Protein Sequence

10 MPALGPALLQ 20 ALWAGWVLTL 30 QPLPPTAFTP 40 NGTYLQHLAR 50 DPTSGTLYLG 60 ATNFLFQLSP 70 GLQLEATVST 80 GPVLDSRDCL 90 PPVMPDECPQ 100 AQPTNNPNQL 110 LLVSPGALVV 120 CGSVHQGVCE 130 QRRLGQLEQL 140 LLRPERPGDT 150 QYVAANDPAV 160 STVGLVAQGL 170 AGEPLLFVGR 180 GYTSRGVGGG 190 IPPITTRALW 200 PPDPQAAFSY 210 EETAKLAVGR 220 LSEYSHHFVS 230 AFARGASAYF 240 LFLRRDLQAQ 250 SRAFRAYVSR 260 VCLRDQHYYS 270 YVELPLACEG 280 GRYGLIQAAA 290 VATSREVAHG 300 EVLFAAFSSA 310 APPTVGRPPS 320 AAAGASGASA 330 LCAFPLDEVD 340 RLANRTRDAC 350 YTREGRAEDG 360 TEVAYIEYDV 370 NSDCAQLPVD 380 TLDAYPCGSD 390 HTPSPMASRV 400 PLEATPILEW 410 PGIQLTAVAV 420 TMEDGHTIAF 430 LGDSQGQLHR 440 VYLGPGSDGH 450 PYSTQSIQQG 460 SAVSRDLTFD 470 GTFEHLYVMT 480 QSTLLKVPVA 490 SCAQHLDCAS 500 CLAHRDPYCG 510 WCVLLGRCSR 520 RSECSRGQGP 530 EQWLWSFQPE 540 LGCLQVAAMS 550 PANISREETR 560 EVFLSVPDLP 570 PLWPGESYSC 580 HFGEHQSPAL 590 LTGSGVMCPS 600 PDPSEAPVLP 610 RGADYVSVSV 620 ELRFGAVVIA 630 KTSLSFYDCV 640 AVTELRPSAQ 650 CQACVSSRWG 660 CNWCVWQHLC 670 THKASCDAGP 680 MVASHQSPLV 690 SPDPPARGGP 700 SPSPPTAPKA 710 LATPAPDTLP 720 VEPGAPSTAT 730 ASDISPGASP 740 SLLSPWGPWA 750 GSGSISSPGS 760 TGSPLHEEPS 770 PPSPQNGPGT 780 AVPAPTDFRP 790 SATPEDLLAS 800 PLSPSEVAAV 810 PPADPGPEAL 820 HPTVPLDLPP 830 ATVPATTFPG 840 AMGSVKPALD 850 WLTREGGELP 860 EADEWTGGDA 870 PAFSTSTLLS 880 GDGDSAELEG 890 PPAPLILPSS 900 LDYQYDTPGL 910 WELEEATLGA 920 SSCPCVESVQ 930 GSTLMPVHVE 940 REIRLLGRNL 950 HLFQDGPGDN 960 ECVMELEGLE 970 VVVEARVECE 980 PPPDTQCHVT 990 CQQHQLSYEA 1000 LQPELRVGLF 1010 LRRAGRLRVD 1020 SAEGLHVVLY 1030 DCSVGHGDCS 1040 RCQTAMPQYG 1050 CVWCEGERPR 1060 CVTREACGEA 1070 EAVATQCPAP 1080 LIHSVEPLTG 1090 PVDGGTRVTI 1100 RGSNLGQHVQ 1110 DVLGMVTVAG 1120 VPCAVDAQEY 1130 EVSSSLVCIT 1140 GASGEEVAGA 1150 TAVEVPGRGR 1160 GVSEHDFAYQ 1170 DPKVHSIFPA 1180 RGPRAGGTRL 1190 TLNGSKLLTG 1200 RLEDIRVVVG 1210 DQPCHLLPEQ 1220 QSEQLRCETS 1230 PRPTPATLPV 1240 AVWFGATERR 1250 LQRGQFKYTL 1260 DPNITSAGPT 1270 KSFLSGGREI 1280 CVRGQNLDVV 1290 QTPRIRVTVV 1300 SRMLQPSQGL 1310 GRRRRVVPET 1320 ACSLGPSCSS 1330 QQFEEPCHVN 1340 SSQLITCRTP 1350 ALPGLPEDPW 1360 VRVEFILDNL 1370 VFDFATLNPT 1380 PFSYEADPTL 1390 QPLNPEDPTM 1400 PFRHKPGSVF 1410 SVEGENLDLA 1420 MSKEEVVAMI 1430 GDGPCVVKTL 1440 TRHHLYCEPP 1450 VEQPLPRHHA 1460 LREAPDSLPE 1470 FTVQMGNLRF 1480 SLGHVQYDGE 1490 SPGAFPVAAQ 1500 VGLGVGTSLL 1510 ALGVIIIVLM 1520 YRRKSKQALR 1530 DYKKVQIQLE 1540 NLESSVRDRC 1550 KKEFTDLMTE 1560 MTDLTSDLLG 1570 SGIPFLDYKV 1580 YAERIFFPGH 1590 RESPLHRDLG 1600 VPESRRPTVE 1610 QGLGQLSNLL 1620 NSKLFLTKFI 1630 HTLESQRTFS 1640 ARDRAYVASL 1650 LTVALHGKLE 1660 YFTDILRTLL 1670 SDLVAQYVAK 1680 NPKLMLRRTE 1690 TVVEKLLTNW 1700 MSICLYTFVR 1710 DSVGEPLYML 1720 FRGIKHQVDK 1730 GPVDSVTGKA 1740 KYTLNDNRLL 1750 REDVEYRPLT 1760 LNALLAVGPG 1770 AGEAQGVPVK 1780 VLDCDTISQA 1790 KEKMLDQLYK 1800 GVPLTQRPDP 1810 RTLDVEWRSG 1820 VAGHLILSDE 1830 DVTSEVQGLW 1840 RRLNTLQHYK 1850 VPDGATVALV 1860 PCLTKHVLRE 1870 NQDYVPGERT 1880 PMLEDVDEGG 1890 IRPWHLVKPS 1900 DEPEPPRPRR 1910 GSLRGGERER 1920 AKAIPEIYLT 1930 RLLSMKGTLQ 1940 KFVDDLFQVI 1950 LSTSRPVPLA 1960 VKYFFDLLDE 1970 QAQQHGISDQ 1980 DTIHIWKTNS 1990 LPLRFWINII 2000 KNPQFVFDVQ 2010 TSDNMDAVLL 2020 VIAQTFMDAC 2030 TLADHKLGRD 2040 SPINKLLYAR 2050 DIPRYKRMVE 2060 RYYADIRQTV 2070 PASDQEMNSV 2080 LAELSWNYSG 2090 DLGARVALHE 2100 LYKYINKYYD 2110 QIITALEEDG 2120 TAQKMQLGYR 2130 LQQIAAAVEN KVTDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0002116 semaphorin receptor complex
Molecular Function GO:0032794 GTPase activating protein binding
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0017154 semaphorin receptor activity
Molecular Function GO:0030215 semaphorin receptor binding
Molecular Function GO:0004888 transmembrane signaling receptor activity
Biological Process GO:0016477 cell migration
Biological Process GO:1904862 inhibitory synapse assembly
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0033689 negative regulation of osteoblast proliferation
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0043931 ossification involved in bone maturation
Biological Process GO:0050772 positive regulation of axonogenesis
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0035025 positive regulation of Rho protein signal transduction
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0051493 regulation of cytoskeleton organization
Biological Process GO:0071526 semaphorin-plexin signaling pathway
Biological Process GO:0007416 synapse assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.