Search Results
Overview
| Uniprot ID | O43157 |
|---|---|
| Protein Name | Plexin-B1 |
| Gene Name | PLXNB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 2131 | IAAAVENKVTDL*** |
Function
Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496)
Protein Sequence
10
MPALGPALLQ
20
ALWAGWVLTL
30
QPLPPTAFTP
40
NGTYLQHLAR
50
DPTSGTLYLG
60
ATNFLFQLSP
70
GLQLEATVST
80
GPVLDSRDCL
90
PPVMPDECPQ
100
AQPTNNPNQL
110
LLVSPGALVV
120
CGSVHQGVCE
130
QRRLGQLEQL
140
LLRPERPGDT
150
QYVAANDPAV
160
STVGLVAQGL
170
AGEPLLFVGR
180
GYTSRGVGGG
190
IPPITTRALW
200
PPDPQAAFSY
210
EETAKLAVGR
220
LSEYSHHFVS
230
AFARGASAYF
240
LFLRRDLQAQ
250
SRAFRAYVSR
260
VCLRDQHYYS
270
YVELPLACEG
280
GRYGLIQAAA
290
VATSREVAHG
300
EVLFAAFSSA
310
APPTVGRPPS
320
AAAGASGASA
330
LCAFPLDEVD
340
RLANRTRDAC
350
YTREGRAEDG
360
TEVAYIEYDV
370
NSDCAQLPVD
380
TLDAYPCGSD
390
HTPSPMASRV
400
PLEATPILEW
410
PGIQLTAVAV
420
TMEDGHTIAF
430
LGDSQGQLHR
440
VYLGPGSDGH
450
PYSTQSIQQG
460
SAVSRDLTFD
470
GTFEHLYVMT
480
QSTLLKVPVA
490
SCAQHLDCAS
500
CLAHRDPYCG
510
WCVLLGRCSR
520
RSECSRGQGP
530
EQWLWSFQPE
540
LGCLQVAAMS
550
PANISREETR
560
EVFLSVPDLP
570
PLWPGESYSC
580
HFGEHQSPAL
590
LTGSGVMCPS
600
PDPSEAPVLP
610
RGADYVSVSV
620
ELRFGAVVIA
630
KTSLSFYDCV
640
AVTELRPSAQ
650
CQACVSSRWG
660
CNWCVWQHLC
670
THKASCDAGP
680
MVASHQSPLV
690
SPDPPARGGP
700
SPSPPTAPKA
710
LATPAPDTLP
720
VEPGAPSTAT
730
ASDISPGASP
740
SLLSPWGPWA
750
GSGSISSPGS
760
TGSPLHEEPS
770
PPSPQNGPGT
780
AVPAPTDFRP
790
SATPEDLLAS
800
PLSPSEVAAV
810
PPADPGPEAL
820
HPTVPLDLPP
830
ATVPATTFPG
840
AMGSVKPALD
850
WLTREGGELP
860
EADEWTGGDA
870
PAFSTSTLLS
880
GDGDSAELEG
890
PPAPLILPSS
900
LDYQYDTPGL
910
WELEEATLGA
920
SSCPCVESVQ
930
GSTLMPVHVE
940
REIRLLGRNL
950
HLFQDGPGDN
960
ECVMELEGLE
970
VVVEARVECE
980
PPPDTQCHVT
990
CQQHQLSYEA
1000
LQPELRVGLF
1010
LRRAGRLRVD
1020
SAEGLHVVLY
1030
DCSVGHGDCS
1040
RCQTAMPQYG
1050
CVWCEGERPR
1060
CVTREACGEA
1070
EAVATQCPAP
1080
LIHSVEPLTG
1090
PVDGGTRVTI
1100
RGSNLGQHVQ
1110
DVLGMVTVAG
1120
VPCAVDAQEY
1130
EVSSSLVCIT
1140
GASGEEVAGA
1150
TAVEVPGRGR
1160
GVSEHDFAYQ
1170
DPKVHSIFPA
1180
RGPRAGGTRL
1190
TLNGSKLLTG
1200
RLEDIRVVVG
1210
DQPCHLLPEQ
1220
QSEQLRCETS
1230
PRPTPATLPV
1240
AVWFGATERR
1250
LQRGQFKYTL
1260
DPNITSAGPT
1270
KSFLSGGREI
1280
CVRGQNLDVV
1290
QTPRIRVTVV
1300
SRMLQPSQGL
1310
GRRRRVVPET
1320
ACSLGPSCSS
1330
QQFEEPCHVN
1340
SSQLITCRTP
1350
ALPGLPEDPW
1360
VRVEFILDNL
1370
VFDFATLNPT
1380
PFSYEADPTL
1390
QPLNPEDPTM
1400
PFRHKPGSVF
1410
SVEGENLDLA
1420
MSKEEVVAMI
1430
GDGPCVVKTL
1440
TRHHLYCEPP
1450
VEQPLPRHHA
1460
LREAPDSLPE
1470
FTVQMGNLRF
1480
SLGHVQYDGE
1490
SPGAFPVAAQ
1500
VGLGVGTSLL
1510
ALGVIIIVLM
1520
YRRKSKQALR
1530
DYKKVQIQLE
1540
NLESSVRDRC
1550
KKEFTDLMTE
1560
MTDLTSDLLG
1570
SGIPFLDYKV
1580
YAERIFFPGH
1590
RESPLHRDLG
1600
VPESRRPTVE
1610
QGLGQLSNLL
1620
NSKLFLTKFI
1630
HTLESQRTFS
1640
ARDRAYVASL
1650
LTVALHGKLE
1660
YFTDILRTLL
1670
SDLVAQYVAK
1680
NPKLMLRRTE
1690
TVVEKLLTNW
1700
MSICLYTFVR
1710
DSVGEPLYML
1720
FRGIKHQVDK
1730
GPVDSVTGKA
1740
KYTLNDNRLL
1750
REDVEYRPLT
1760
LNALLAVGPG
1770
AGEAQGVPVK
1780
VLDCDTISQA
1790
KEKMLDQLYK
1800
GVPLTQRPDP
1810
RTLDVEWRSG
1820
VAGHLILSDE
1830
DVTSEVQGLW
1840
RRLNTLQHYK
1850
VPDGATVALV
1860
PCLTKHVLRE
1870
NQDYVPGERT
1880
PMLEDVDEGG
1890
IRPWHLVKPS
1900
DEPEPPRPRR
1910
GSLRGGERER
1920
AKAIPEIYLT
1930
RLLSMKGTLQ
1940
KFVDDLFQVI
1950
LSTSRPVPLA
1960
VKYFFDLLDE
1970
QAQQHGISDQ
1980
DTIHIWKTNS
1990
LPLRFWINII
2000
KNPQFVFDVQ
2010
TSDNMDAVLL
2020
VIAQTFMDAC
2030
TLADHKLGRD
2040
SPINKLLYAR
2050
DIPRYKRMVE
2060
RYYADIRQTV
2070
PASDQEMNSV
2080
LAELSWNYSG
2090
DLGARVALHE
2100
LYKYINKYYD
2110
QIITALEEDG
2120
TAQKMQLGYR
2130
LQQIAAAVEN
KVTDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0002116 | semaphorin receptor complex |
| Molecular Function | GO:0032794 | GTPase activating protein binding |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0017154 | semaphorin receptor activity |
| Molecular Function | GO:0030215 | semaphorin receptor binding |
| Molecular Function | GO:0004888 | transmembrane signaling receptor activity |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:1904862 | inhibitory synapse assembly |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0007162 | negative regulation of cell adhesion |
| Biological Process | GO:0033689 | negative regulation of osteoblast proliferation |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0043931 | ossification involved in bone maturation |
| Biological Process | GO:0050772 | positive regulation of axonogenesis |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0035025 | positive regulation of Rho protein signal transduction |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0051493 | regulation of cytoskeleton organization |
| Biological Process | GO:0071526 | semaphorin-plexin signaling pathway |
| Biological Process | GO:0007416 | synapse assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.