Search Results
Overview
| Uniprot ID | O43164 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase Praja-2 |
| Gene Name | PJA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 320 | VVRPKVRKLISSSQV |
Function
Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390)
Protein Sequence
10
MSQYTEKEPA
20
AMDQESGKAV
30
WPKPAGGYQT
40
ITGRRYGRRH
50
AYVSFKPCMT
60
RHERSLGRAG
70
DDYEVLELDD
80
VPKENSSGSS
90
PLDQVDSSLP
100
SEPIFEKSET
110
EIPTCGSALN
120
QTTESSQSFV
130
AVHHSEEGRD
140
TLGSSTNLHN
150
HSEGEYIPGA
160
CSASSVQNGI
170
ALVHTDSYDP
180
DGKHGEDNDH
190
LQLSAEVVEG
200
SRYQESLGNT
210
VFELENREAE
220
AYTGLSPPVP
230
SFNCEVRDEF
240
EELDSVPLVK
250
SSAGDTEFVH
260
QNSQEIQRSS
270
QDEMVSTKQQ
280
NNTSQERQTE
290
HSPEDAACGP
300
GHICSEQNTN
310
DREKNHGSSP
320
EQVVRPKVRK
330
LISSSQVDQE
340
TGFNRHEAKQ
350
RSVQRWREAL
360
EVEESGSDDL
370
LIKCEEYDGE
380
HDCMFLDPPY
390
SRVITQRETE
400
NNQMTSESGA
410
TAGRQEVDNT
420
FWNGCGDYYQ
430
LYDKDEDSSE
440
CSDGEWSASL
450
PHRFSGTEKD
460
QSSSDESWET
470
LPGKDENEPE
480
LQSDSSGPEE
490
ENQELSLQEG
500
EQTSLEEGEI
510
PWLQYNEVNE
520
SSSDEGNEPA
530
NEFAQPAFML
540
DGNNNLEDDS
550
SVSEDLDVDW
560
SLFDGFADGL
570
GVAEAISYVD
580
PQFLTYMALE
590
ERLAQAMETA
600
LAHLESLAVD
610
VEVANPPASK
620
ESIDGLPETL
630
VLEDHTAIGQ
640
EQCCPICCSE
650
YIKDDIATEL
660
PCHHFFHKPC
670
VSIWLQKSGT
680
CPVCRRHFPP
690
AVIEASAAPS
700
SEPDPDAPPS
NDSIAEAP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034451 | centriolar satellite |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0007616 | long-term memory |
| Biological Process | GO:0141163 | positive regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0046330 | positive regulation of JNK cascade |
| Biological Process | GO:1900745 | positive regulation of p38MAPK cascade |
| Biological Process | GO:0034137 | positive regulation of toll-like receptor 2 signaling pathway |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0043030 | regulation of macrophage activation |
Reference
PMID: N/A