Search Results

Overview

Uniprot IDO43175
Protein NameD-3-phosphoglycerate dehydrogenase
Gene NamePHGDH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
21 SLDPCCRKILQDGGL
289 PHLGASTKEAQSRCG
33 GGLQVVEKQNLSKEE
351 RAWAGSPKGTIQVIT
384 GLLKEASKQADVNLV
394 DVNLVNAKLLVKEAG
58 LIVRSATKVTADVIN
69 DVINAAEKLQVVGRA
8 MAFANLRKVLISDSL

Function

Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate

Protein Sequence

10 MAFANLRKVL 20 ISDSLDPCCR 30 KILQDGGLQV 40 VEKQNLSKEE 50 LIAELQDCEG 60 LIVRSATKVT 70 ADVINAAEKL 80 QVVGRAGTGV 90 DNVDLEAATR 100 KGILVMNTPN 110 GNSLSAAELT 120 CGMIMCLARQ 130 IPQATASMKD 140 GKWERKKFMG 150 TELNGKTLGI 160 LGLGRIGREV 170 ATRMQSFGMK 180 TIGYDPIISP 190 EVSASFGVQQ 200 LPLEEIWPLC 210 DFITVHTPLL 220 PSTTGLLNDN 230 TFAQCKKGVR 240 VVNCARGGIV 250 DEGALLRALQ 260 SGQCAGAALD 270 VFTEEPPRDR 280 ALVDHENVIS 290 CPHLGASTKE 300 AQSRCGEEIA 310 VQFVDMVKGK 320 SLTGVVNAQA 330 LTSAFSPHTK 340 PWIGLAEALG 350 TLMRAWAGSP 360 KGTIQVITQG 370 TSLKNAGNCL 380 SPAVIVGLLK 390 EASKQADVNL 400 VNAKLLVKEA 410 GLNVTTSHSP 420 AAPGEQGFGE 430 CLLAVALAGA 440 PYQAVGLVQG 450 TTPVLQGLNG 460 AVFRPEVPLR 470 RDLPLLLFRT 480 QTSDPAMLPT 490 MIGLLAEAGV 500 RLLSYQTSLV 510 SDGETWHVMG 520 ISSLLPSLEA 530 WKQHVTEAFQ FHF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0120568 (R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0030060 L-malate dehydrogenase (NAD+) activity
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0004617 phosphoglycerate dehydrogenase activity
Biological Process GO:0007420 brain development
Biological Process GO:0006564 L-serine biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.